2. Academic Validation
  3. Cadherin-responsive hydrogel combined with dental pulp stem cells and fibroblast growth factor 21 promotes diabetic scald repair via regulating epithelial-mesenchymal transition and necroptosis

Cadherin-responsive hydrogel combined with dental pulp stem cells and fibroblast growth factor 21 promotes diabetic scald repair via regulating epithelial-mesenchymal transition and necroptosis

  • Mater Today Bio. 2023 Dec 22:24:100919. doi: 10.1016/j.mtbio.2023.100919.
Wenjie Lu 1 2,  Juan Zhao 1 2,  Xiong Cai 1 2,  Yutian Wang 1 2,  Wenwei Lin 1 2,  Yaoping Fang 1 2,  Yunyang Wang 1 2,  Jinglei Ao 1 2,  Jiahui Shou 1 2,  Jiake Xu 1 3 4,  Sipin Zhu 1 2
Affiliations

Affiliations

  • 1 Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, 325000 China.
  • 2 School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
  • 3 Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
  • 4 School of Biomedical Sciences, University of Western Australia, Perth, Western Australia, 6009, Australia.
PMID: 38298888 DOI: 10.1016/j.mtbio.2023.100919
Abstract

Diabetes causes a loss of sensation in the skin, so diabetics are prone to burns when using heating devices. Diabetic scalded skin is often difficult to heal due to the microenvironment of high glucose, high oxidation, and low blood perfusion. The treatment of diabetic scald mainly focuses on three aspects: 1) promote the formation of the epithelium; 2) promote angiogenesis; and 3) maintain intracellular homeostasis. In response to these three major repair factors, we developed a cadherin-responsive hydrogel combined with FGF21 and dental pulp stem cells (DPSCs) to accelerate epithelial formation by recruiting Cadherin to the epidermis and promoting the transformation of N Cadherin to E cadherin; promoting angiogenesis to increase wound blood perfusion; regulating the stability of lysosomal and activating Autophagy to maintain intracellular homeostasis in order to comprehensively advance the recovery of diabetic scald.

Keywords

Cadherin-responsive; Diabetic scald; Epithelial-mesenchymal transition; Fibroblast growth factor 21; Lysosomal stability.

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