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  3. A spike virosome vaccine induces pan-sarbecovirus antibody responses in mice

A spike virosome vaccine induces pan-sarbecovirus antibody responses in mice

  • iScience. 2024 Apr 10;27(5):109719. doi: 10.1016/j.isci.2024.109719.
Mitch Brinkkemper 1 2,  Meliawati Poniman 1 2,  Esther Siteur-van Rijnstra 3,  Widad Ait Iddouch 1 2,  Tom P L Bijl 1 2,  Denise Guerra 1 2,  Khadija Tejjani 1 2,  Marloes Grobben 1 2,  Farien Bhoelan 4,  Denzel Bemelman 4,  Ronald Kempers 4,  Marit J van Gils 1 2,  Kwinten Sliepen 1 2,  Toon Stegmann 4,  Yme U van der Velden 1 2,  Rogier W Sanders 1 2 5
Affiliations

Affiliations

  • 1 Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands.
  • 2 Amsterdam institute for Infection and Immunity, Infectious diseases, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands.
  • 3 Amsterdam UMC, location University of Amsterdam, Department of Experimental Immunology, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands.
  • 4 Mymetics BV, JH Oortweg 21, CH 2333 Leiden, the Netherlands.
  • 5 Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA.
PMID: 38706848 DOI: 10.1016/j.isci.2024.109719
Abstract

Zoonotic events by sarbecoviruses have sparked an epidemic (severe acute respiratory syndrome coronavirus [SARS-CoV]) and a pandemic (SARS-CoV-2) in the past two decades. The continued risk of spillovers from Animals to humans is an ongoing threat to global health and a pan-sarbecovirus vaccine would be an important contribution to pandemic preparedness. Here, we describe multivalent virosome-based vaccines that present stabilized spike proteins from four sarbecovirus strains, one from each clade. A cocktail of four monovalent virosomes or a mosaic virosome preparation induced broad sarbecovirus binding and neutralizing antibody responses in mice. Pre-existing immunity against SARS-CoV-2 and extending the intervals between immunizations enhanced antibody responses. These results should inform the development of a pan-sarbecovirus vaccine, as part of our efforts to prepare for and/or avoid a next pandemic.

Keywords

Immunology; Virology.

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