2. Academic Validation
  3. Raddeanin A Protects the BRB Through Inhibiting Inflammation and Apoptosis in the Retina of Alzheimer's Disease

Raddeanin A Protects the BRB Through Inhibiting Inflammation and Apoptosis in the Retina of Alzheimer's Disease

  • Neurochem Res. 2024 Aug;49(8):2197-2214. doi: 10.1007/s11064-024-04145-5.
Xiao-Fang Wang # 1 2,  Xiao-Hong Xiang # 3,  Jing Wei # 4,  Peng-Bo Zhang # 5,  Qin Xu 3,  Meng-Han Liu 6,  Li-Qun Qu 6,  Xing-Xia Wang 6,  Lu Yu 7,  An-Guo Wu 7,  Da-Lian Qing 7,  Jian-Ming Wu 2 7,  Betty Yuen-Kwan Law 8,  Chong-Lin Yu 9,  Yong-Tang 10 11 12
Affiliations

Affiliations

  • 1 Laboratory Animal Centre, Model Animal and Human Disease Research of Luzhou Key Laboratory, Southwest Medical University, Luzhou, China.
  • 2 School of Basic Medical Sciences of Southwest Medical University, Luzhou, China.
  • 3 Department of Ophthalmology in The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China.
  • 4 Eye School and Key Laboratory of Sichuan Province Ophthalmopathy Prevention & Cure and Visual Function Protection of Chengdu University of TCM, Chengdu, China.
  • 5 Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, 15651, China.
  • 6 Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine and Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, China.
  • 7 Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica of Southwest Medical University, Luzhou, 646000, China.
  • 8 Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine and Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, China. [email protected].
  • 9 School of Basic Medical Sciences of Southwest Medical University, Luzhou, China. [email protected].
  • 10 Laboratory Animal Centre, Model Animal and Human Disease Research of Luzhou Key Laboratory, Southwest Medical University, Luzhou, China. [email protected].
  • 11 Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine and Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, China. [email protected].
  • 12 School of Basic Medical Sciences of Southwest Medical University, Luzhou, China. [email protected].
  • # Contributed equally.
PMID: 38834846 DOI: 10.1007/s11064-024-04145-5
Abstract

Neuroinflammation and endothelial cell Apoptosis are prominent features of blood-brain barrier (BBB) disruption, which have been described in Alzheimer's disease (AD) and can predict cognitive decline. Recent reports revealed vascular β-amyloid (Aβ) deposits, Muller cell degeneration and microglial dysfunction in the retina of AD patients. However, there has been no in-depth research on the roles of inflammation, retinal endothelial cell Apoptosis, and blood-retinal barrier (BRB) damage in AD retinopathy. We found that Raddeanin A (RDA) could improve pathological and cognitive deficits in a mouse model of Alzheimer's disease by targeting β-amyloidosis, However, the effects of RDA on AD retinal function require further study. To clarify whether RDA inhibits inflammation and Apoptosis and thus improves BRB function in AD-related retinopathy. In vitro we used Aβ-treated HRECs and MIO-M1 cells, and in vivo we used 3×Tg-AD mice to investigate the effect of RDA on BRB in AD-related retinopathy. We found that RDA could improve BRB function in AD-related retinopathy by inhibiting NLRP3-mediated inflammation and suppressing Wnt/β-catenin pathway-mediated Apoptosis, which is expected to improve the pathological changes in AD-related retinopathy and the quality of life of AD patients.

Keywords

Alzheimer’s disease; Apoptosis; Blood-retinal barrier; Inflammation; Retina.

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