2. Academic Validation
  3. Geministatins: new depside antibiotics from the fungus Austroacremonium gemini

Geministatins: new depside antibiotics from the fungus Austroacremonium gemini

  • J Antibiot (Tokyo). 2024 Oct;77(10):639-646. doi: 10.1038/s41429-024-00755-x.
Andrew Crombie 1,  John A Kalaitzis 2,  Rachel Chen 1,  Daniel Vuong 1,  Alastair E Lacey 1,  Ernest Lacey 1 2,  Roger G Shivas 3 4,  Yu Pei Tan 3 4,  Nicolau Sbaraini 5,  Yit-Heng Chooi 5,  Andrew M Piggott 6
Affiliations

Affiliations

  • 1 Microbial Screening Technologies, Smithfield, NSW, 2164, Australia.
  • 2 School of Natural Sciences, Macquarie University, Sydney, NSW, 2109, Australia.
  • 3 Department of Agriculture and Fisheries, Plant Pathology Herbarium, Dutton Park, QLD, 4102, Australia.
  • 4 Centre for Crop Health, University of Southern Queensland, Toowoomba, QLD, 4350, Australia.
  • 5 School of Molecular Sciences, The University of Western Australia, Perth, WA, 6009, Australia.
  • 6 School of Natural Sciences, Macquarie University, Sydney, NSW, 2109, Australia. [email protected].
PMID: 38926492 DOI: 10.1038/s41429-024-00755-x
Abstract

Two new depside Antibiotics, geministatins A (1) and B (2), were isolated from the fungus Austroacremonium gemini MST-FP2131 (Sordariomycetes, Ascomycota), which was recovered from rotting wood in the wet tropics of northern Australia. The structures of the geministatins were elucidated by detailed spectroscopic analysis, chemical degradation and comparison with literature values. Chemical degradation of 1 and 2 yielded three new analogues, geministatins C-E (3-5), as well as a previously reported compound dehydromerulinic acid A (6). Compounds 1, 2 and 6 exhibited Antibacterial activity against the Gram-positive bacteria Bacillus subtilis (MIC 0.2-1.6 µg mL-1) and Staphylococcus aureus (MIC 0.78-6.3 µg mL-1), including methicillin-resistant S. aureus (MRSA), while 4 exhibited Antifungal activity against the yeast Saccharomyces cerevisiae (MIC 13 µg mL-1).

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