2. Anti-infection Others
  3. Fungal Drug Derivative
  4. Geministatin D

Geministatin D is a derivative of Geministatin A that retains the C17 (Z,Z)-diene alkyl side chain but lacks the complete diester backbone. As a chemical degradation fragment of the parent compound, Geministatin D shows weak antibacterial activity against Gram-positive bacteria but exerts mild inhibitory effects on Saccharomyces cerevisiae. Geministatin D can be used in studies on fungal infections caused by Saccharomyces cerevisiae.

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Geministatin D

Geministatin D Chemical Structure

CAS No. : 3131756-58-3

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Geministatin D Related Antibodies

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Description

Geministatin D is a derivative of Geministatin A that retains the C17 (Z,Z)-diene alkyl side chain but lacks the complete diester backbone. As a chemical degradation fragment of the parent compound, Geministatin D shows weak antibacterial activity against Gram-positive bacteria but exerts mild inhibitory effects on Saccharomyces cerevisiae. Geministatin D can be used in studies on fungal infections caused by Saccharomyces cerevisiae[1].

In Vitro

Geministatin D inhibits the growth of Bacillus subtilis with an MIC of 25 μg/mL; however, it shows no inhibitory effect on the growth of Staphylococcus aureus or methicillin-resistant Staphylococcus aureus even at concentrations as high as 100 μg/mL[1].
Geministatin D inhibits the growth of Saccharomyces cerevisiae with an MIC of 13 μg/mL[1].
Geministatin D exhibits cytotoxicity against mouse myeloma NS-1 cells with an IC50 of 68 μM, but shows no significant cytotoxicity toward neonatal foreskin fibroblasts even at concentrations as high as 180 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Geministatin D Related Antibodies
Molecular Weight

550.68

Formula

C30H46O9
CAS No.
SMILES

O[C@H]1[C@H](OC2=CC(CCCCCCC/C=C\C/C=C\CCCCC)=C(C(O)=O)C(O)=C2)O[C@H](CO)[C@H](O)[C@@H]1O
Structure Classification
Initial Source

Austroacremonium gemini
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Geministatin D Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Geministatin D3131756-58-3FungalDrug DerivativeDrug derivativemethicillin-resistant S. aureusmouse myeloma NS-1 cellsStaphylococcus aureusBacillus subtilisneonatal foreskin fibroblast cellsfungal infectionSaccharomyces cerevisiaeInhibitorinhibitorinhibit

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