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Cat. No.: HY-N19233

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Geministatin B

Geministatin B is a potent antibiotic that can be found in the fungus Austroacremonium gemini MST-FP2131. Geministatin B exhibits antibacterial activity against Gram-positive bacteria including Bacillus subtilis, Staphylococcus aureus, and methicillin-resistant S. aureus (MRSA). Geministatin B can be used for the research of bacterial infections.

For research use only. We do not sell to patients.

Formula: C₃₂H₄₂O₇
Molecular Weight:538.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Geministatin B Chemical Structure

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Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

All Antibiotic Isoforms :

In Vitro

Geministatin B exhibits potent antibacterial activity against Bacillus subtilis (MIC = 0.39 µg/mL), Staphylococcus aureus (MIC = 3.1 µg/mL), and MRSA (MIC = 1.6 µg/mL)^[1].
Geministatin B shows no antifungal activity against Saccharomyces cerevisiae with MIC > 200 µg/mL^[1].
Geministatin B shows low cytotoxicity against mouse myeloma NS-1 cells (IC₅₀ = 93 µM) and neonatal foreskin fibroblast cells (IC₅₀ >190 µM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 538.67
Formula C₃₂H₄₂O₇
SMILES

O=C(OC1=CC(O)=C(C(O)=O)C(C)=C1)C2=C(CCCCCCC/C=C\C/C=C\CCCCC)C=C(O)C=C2O
Structure Classification
- Others
- Antibiotics
Initial Source
- Microorganisms
Austroacremonium gemini
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Crombie A, et al. Geministatins: new depside antibiotics from the fungus Austroacremonium gemini. J Antibiot (Tokyo). 2024 Oct;77(10):639-646. [Content Brief]

[2]. Qiaolin Ji, et al. Biosynthesis of Depsides, Depsidones, and Diphenyl Ethers from Fungi and Lichens. Asian J. Org. Chem. 2025, 14, e202400451.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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Geministatin B

All Antibiotic Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Geministatin B Related Classifications

HY-N19233 Related Classifications