2. Academic Validation
  3. Cyclic Peptides Targeting Granzyme B: Potential Applications as PET Imaging Agents

Cyclic Peptides Targeting Granzyme B: Potential Applications as PET Imaging Agents

  • ACS Med Chem Lett. 2025 Jan 6;16(2):180-181. doi: 10.1021/acsmedchemlett.4c00608.
Qi-Long Hu 1,  Steven H Liang 1
Affiliations

Affiliation

  • 1 Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia 30322, United States.
PMID: 39967616 DOI: 10.1021/acsmedchemlett.4c00608
Abstract

This patent application pertains to macrocyclic peptides and their radiolabeled derivatives, generally represented by Formula I. These compounds exhibit selective binding to Granzyme B (GzmB) and hold the potential for imaging disease or disorders associated with elevated GzmB levels. Such conditions include Cancer Immunotherapy, autoimmunity, wound healing, and inflammation.

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