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Cat. No.: HY-P11835

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Granzyme B contrast agent-1

Granzyme B contrast agent-1 is a Granzyme B binder with a K_d value of 1.0 nM. When radiolabeled, Granzyme B contrast agent-1 can be used for positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging studies of Granzyme B.

For research use only. We do not sell to patients.

CAS No.: 3062270-62-3
Formula: C₁₃₄H₁₇₀N₂₆O₃₄S₂
Molecular Weight:2753.07

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Custom Peptide Synthesis

Granzyme B contrast agent-1 Chemical Structure

CAS No.: 3062270-62-3

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- Description
- IC₅₀ & Target
- In Vitro
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Biological Activity

Description

IC₅₀ & Target^[1]

RDC Peptide

All Radionuclide-Drug Conjugates (RDCs) Isoforms :

In Vitro

Granzyme B contrast agent-1 (Compound 3a) binds to purified granzyme B with a K_d value of 1.0 nM^[1].
Granzyme B contrast agent-1 (0.01-1 μM) binds to purified granzyme B, with an equilibrium dissociation constant (K_d) of 1.1 nM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3062270-62-3
Molecular Weight 2753.07
Formula C₁₃₄H₁₇₀N₂₆O₃₄S₂
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Idriss BENNACEF, et al. Cyclic peptides as pet imaging agents of granzyme b. WO2024228936A1. WIPO (PCT). 2024-04-29.

[2]. Hu QL, et al. Cyclic Peptides Targeting Granzyme B: Potential Applications as PET Imaging Agents. ACS medicinal chemistry letters. 2025 Feb 13;16(2):180-181. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Granzyme B contrast agent-1

All Radionuclide-Drug Conjugates (RDCs) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Granzyme B contrast agent-1 Related Classifications

HY-P11835 Related Classifications