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Granzyme B contrast agent-1

Granzyme B contrast agent-1 is a Granzyme B binder with a K_d value of 1.0 nM. When radiolabeled, Granzyme B contrast agent-1 can be used for positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging studies of Granzyme B.

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No. CAS: 3062270-62-3
Fòrmula: C₁₃₄H₁₇₀N₂₆O₃₄S₂
Peso molecular:2753.07

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Granzyme B contrast agent-1 Chemical Structure

No. CAS: 3062270-62-3

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^[1]

RDC Peptide

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In Vitro

Granzyme B contrast agent-1 (Compound 3a) binds to purified granzyme B with a K_d value of 1.0 nM^[1].
Granzyme B contrast agent-1 (0.01-1 μM) binds to purified granzyme B, with an equilibrium dissociation constant (K_d) of 1.1 nM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 3062270-62-3
Peso molecular 2753.07
Fòrmula C₁₃₄H₁₇₀N₂₆O₃₄S₂
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Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

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Instrucciones de manejo (2659 KB)

Referencias

[1]. Idriss BENNACEF, et al. Cyclic peptides as pet imaging agents of granzyme b. WO2024228936A1. WIPO (PCT). 2024-04-29.

[2]. Hu QL, et al. Cyclic Peptides Targeting Granzyme B: Potential Applications as PET Imaging Agents. ACS medicinal chemistry letters. 2025 Feb 13;16(2):180-181. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Granzyme B contrast agent-1

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Granzyme B contrast agent-1

Ver todos los productos específicos de isoformas Radionuclide-Drug Conjugates (RDCs)

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