2. Academic Validation
  3. A High-Fiber Plant-Based Diet in Myeloma Precursor Disorders - Results from the NUTRIVENTION Clinical Trial and Preclinical Vk*MYC Model

A High-Fiber Plant-Based Diet in Myeloma Precursor Disorders - Results from the NUTRIVENTION Clinical Trial and Preclinical Vk*MYC Model

  • Cancer Discov. 2025 Dec 4. doi: 10.1158/2159-8290.CD-25-1101.
Urvi A Shah 1,  Laura Lucia Cogrossi 2,  Juan-Jose Garces 3,  Anna Policastro 2,  Francesca Castro 1,  Andriy Derkach 1,  Teng Fei 3,  Susan DeWolf 1,  Matteo Grioni 2,  Sofia Sisti 4,  Jenna Blaslov 1,  Peter A Adintori 1,  Kinga K Hosszu 1,  Devin McAvoy 3,  Mirae Baichoo 1,  Justin R Cross 3,  Jenny Paredes 5,  Aishwarya Anuraj 1,  Sandeep S Raj 3,  Charlotte Pohl 6,  Paola Zordan 7,  Victoria Zinsmeyer 1,  Ruben J Jesus Faustino Ramos 8,  Marco Lorenzoni 2,  Brianna Gipson 1,  Kylee H Maclachlan 1,  Ana Gradissimo 3,  Leonardo Boiocchi 1,  Nathan Aleynick 9,  Camilla Marchigiani 2,  Sara Pagani 2,  Erica Salehi 1,  Richard P Koche 3,  Ronan Chaligne 1,  Torin Block 10,  Neha Korde 1,  Carlyn R Tan 1,  Malin Hultcrantz 1,  Hani Hassoun 1,  Gunjan L Shah 3,  Michael Scordo 1,  Oscar B Lahoud 11,  David J Chung 12,  Heather J Landau 1,  Jonathan U Peled 1,  Nicola Clementi 4,  Marta Chesi 13,  P Leif Bergsagel 13,  Sham Mailankody 3,  Michael N Pollak 14,  Anita D'Souza 15,  Ola Landgren 16,  Susan Chimonas 1,  Sergio A Giralt 6,  Saad Z Usmani 1,  Neil M Iyengar 17,  Alexander M Lesokhin 1,  Marcel R M van den Brink 18,  Matteo Bellone 2
Affiliations

Affiliations

  • 1 Memorial Sloan Kettering Cancer Center, New York, NY, United States.
  • 2 IRCCS Ospedale San Raffaele, Milan, Italy.
  • 3 Memorial Sloan Kettering Cancer Center, New York, United States.
  • 4 Vita-Salute San Raffaele University, Milan, Italy.
  • 5 City of Hope, Los Angeles, California, United States.
  • 6 Memorial Sloan Kettering Cancer Center, New York, New York, United States.
  • 7 San Raffaele Scientific Institute, Milano, Italy, Italy.
  • 8 Memorial Sloan Kettering Cancer Center, New York City, New York, United States.
  • 9 Memorial Sloan Kettering Cancer Center, United States.
  • 10 NutritionQuest (United States), Berkeley, CA, United States.
  • 11 NYU Langone's Laura and Isaac Perlmutter Cancer Center, Brooklyn, NY, United States.
  • 12 Northwell Health, New York, NY, United States.
  • 13 Mayo Clinic, Scottsdale, AZ, United States.
  • 14 McGill University, Montreal, Quebec, Canada.
  • 15 Medical College of Wisconsin, United States.
  • 16 Sylvester Comprehensive Cancer Center, Miami, FL, United States.
  • 17 Memorial Sloan Kettering Cancer Center, Atlanta, GA, United States.
  • 18 City Of Hope National Medical Center, California, United States.
PMID: 41342739 DOI: 10.1158/2159-8290.CD-25-1101
Abstract

Consumption of a western diet and high body mass index (BMI) are risk factors for progression from pre-malignant phenotypes to multiple myeloma, a hematologic Cancer. In the NUTRIVENTION trial (NCT04920084), we administered a high-fiber, plant-based diet (meals for 12 weeks, coaching for 24 weeks) to 23 participants with myeloma precursor states and elevated BMI. The intervention was feasible, improved quality of life and modifiable risk factors: metabolic (BMI, Insulin resistance), microbiome (diversity, composition), and immune (inflammation, monocyte subsets). Disease-progression trajectory improved (n=2) or was stable. Findings were translated to Vk*MYC mice modeling the myeloma-precursor state, in which a high-fiber diet delayed disease progression through improved metabolism and microbiome composition leading to increased short-chain fatty acid production that reinvigorated anti-tumor immunity and inhibited tumor growth. These effects from fiber consumption were independent of calorie restriction and weight loss. A high-fiber diet is a low-risk intervention that may delay progression to myeloma.

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