Antimelanogenesis and antioxidant activity of Broussonetia papyrifera leaf extract fermentation broth

Broussonetia papyrifera leaves are a medicinal plant rich in bioactive substances. This study utilized microbial fermentation of B. papyrifera leaf extract (BLE) to screen out Lactobacillus rhamnosus and Bifidobacterium papyrifera as the most suitable fermentation strains. The total Phenols, total Flavonoids, total tannins and total triterpenoids content increased after fermentation. The fermentation broth of L. rhamnosus and BLE (BLFs) could inhibit the Tyrosinase, melanin production and related protein expression of mouse melanoma cell B16-F10. The fermentation broth of B. bifidum and BLE (BBFs) exhibited significant antioxidant effects. It indicates that the fermented BLE has great application potential in the fields of medicine, cosmetics and related areas.

Broussonetia papyrifera leaf fermentation broth; antioxidant activity; probiotic fermentation; tyrosinase inhibition.