2. Academic Validation
  3. The NLRP3 inhibitor, MCC950, attenuates environmental pollutant PM2.5-induced acute lung injury by inhibiting alveolar macrophage pyroptosis

The NLRP3 inhibitor, MCC950, attenuates environmental pollutant PM2.5-induced acute lung injury by inhibiting alveolar macrophage pyroptosis

  • Curr Res Toxicol. 2026 Jan 22:10:100282. doi: 10.1016/j.crtox.2026.100282.
Zhuoxiao Han 1,  Ying Han 2,  Ranran Li 3 4,  Kexin Fan 1,  Xiao Zhang 5,  Tengfei Sun 6,  Yue Li 7,  Hua Qiao 1
Affiliations

Affiliations

  • 1 Department of Pulmonary and Critical Care Medicine, the First Hospital of Qinhuangdao, Qinhuangdao 066000, China.
  • 2 Department of Neurosurgery, the First Hospital of Qinhuangdao, Qinhuangdao 066000, China.
  • 3 School of Economics and Management, Yanshan University, Qinhuangdao 066004, China.
  • 4 Collaborative Innovation Center of Industry Development of Coast Area, Qinhuangdao 066004, China.
  • 5 Department of Neurosurgery, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China.
  • 6 Department of Gastroenterology, the First Hospital of Qinhuangdao, Qinhuangdao 066000, China.
  • 7 Medical department, the First Hospital of Qinhuangdao, Qinhuangdao 066000, China.
PMID: 41743188 DOI: 10.1016/j.crtox.2026.100282
Abstract

PM2.5 is a key environmental pollutant that induces inflammatory lung injury. Effective prevention and treatment for PM2.5-induced lung damage remain lacking. This study investigated MCC950's protective role in PM2.5-exposed mice and macrophages. PM2.5 triggers NLRP3/Caspase-1-mediated Pyroptosis, amplifying pulmonary inflammation. MCC950 attenuates injury by inhibiting Pyroptosis, suggesting therapeutic potential.

Keywords

Alveolar macrophage; MCC950; NLRP3; PM2.5; Pyroptosis.

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