2. Academic Validation
  3. When Potency Is Not Enough: Aligning Modality, Exposure, and Biology

When Potency Is Not Enough: Aligning Modality, Exposure, and Biology

  • ACS Med Chem Lett. 2026 Feb 23;17(3):625-627. doi: 10.1021/acsmedchemlett.6c00080.
Anna C Renner 1,  Robert B Kargbo 2
Affiliations

Affiliations

  • 1 North Dakota State University, Fargo, North Dakota 58108-6050, United States.
  • 2 Independent Research Consultant, Middleton, Wisconsin 53562, United States.
PMID: 41847654 DOI: 10.1021/acsmedchemlett.6c00080
Abstract

Recent patent disclosures illustrate how modern medicinal chemistry advances by aligning biological insight with chemical modality, formulation rigor, and molecular measurement. Targeted protein degradation to overcome resistance, solid-state engineering to ensure sustained pathway suppression, and single-cell genomic profiling to resolve metastatic biology together demonstrate how therapeutic impact emerges when perturbation, delivery, and biological observability are coherently integrated.

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