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Art. -Nr.: HY-181813

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PROTAC DHFR Degrader-1

PROTAC DHFR Degrader-1 is a selective PROTAC degrader targeting Plasmodium falciparum DHFR-TS with a K_i of 2.01 nM. PROTAC DHFR Degrader-1 exhibits no inhibitory activity against human DHFR and suppresses the growth of Plasmodium falciparum. PROTAC DHFR Degrader-1 can be used for the research of Plasmodium falciparum and malaria.
(Pink: ligand (HY-153007); Blue: MDM-2/p53 ligand (HY-15676); Black: linker).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3077918-47-6
Formel: C₅₃H₆₀Cl₂F₂N₈O₉
Molecular Weight:1061.99

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

PROTAC DHFR Degrader-1 Chemical Structure

CAS. Nr.: 3077918-47-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

PROTAC DHFR Degrader-1 is a selective PROTAC degrader targeting Plasmodium falciparum DHFR-TS with a K_i of 2.01 nM. PROTAC DHFR Degrader-1 exhibits no inhibitory activity against human DHFR and suppresses the growth of Plasmodium falciparum. PROTAC DHFR Degrader-1 can be used for the research of Plasmodium falciparum and malaria^[1]. (Pink: ligand (HY-153007); Blue: MDM-2/p53 ligand (HY-15676); Black: linker).

IC₅₀ & Target

^[1]

Plasmodium

2.01 nM (Ki)

MDM2

Alle PROTACs Isoform-spezifische Produkte anzeigen :

Alle Parasite Isoform-spezifische Produkte anzeigen :

In Vitro

PROTAC DHFR Degrader-1 (IId) potently inhibits wild-type Plasmodium falciparum dihydrofolate reductase (DHFR-TS) with a mean K_i of 2.01 nM and does not inhibit human dihydrofolate reductase at concentrations up to 100,000 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3077918-47-6
Molecular Weight 1061.99
Formel C₅₃H₆₀Cl₂F₂N₈O₉
SMILES

O=C(NCCOCCOC1=CC=C(OCCCOC2=C(N=C(N=C2CC)N)N)C(CCC(O)=O)=C1)C3=CC(OC)=C(NC([C@@H]4N[C@@H](CC(C)(C)C)[C@]([C@H]4C5=CC=CC(Cl)=C5F)(C#N)C6=CC=C(Cl)C=C6F)=O)C=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Renner AC, et al. When Potency Is Not Enough: Aligning Modality, Exposure, and Biology. ACS Med Chem Lett. 2026;17(3):625-627. Published 2026 Feb 23. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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