PROTAC DHFR Degrader-1
PROTAC DHFR Degrader-1 is a selective PROTAC degrader targeting Plasmodium falciparum DHFR-TS with a Ki of 2.01 nM. PROTAC DHFR Degrader-1 exhibits no inhibitory activity against human DHFR and suppresses the growth of Plasmodium falciparum. PROTAC DHFR Degrader-1 can be used for the research of Plasmodium falciparum and malaria.
(Pink: Dihydrofolate reductase (DHFR) ligand (HY-153007); Blue: MDM-2/p53 ligand (HY-15676); Black: linker).
For research use only. We do not sell to patients.
- CAS No.: 3077918-47-6
- Formula: C53H60Cl2F2N8O9
- Molecular Weight:1061.99
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Plasmodium 2.01 nM (Ki) |
MDM2 |
PROTAC DHFR Degrader-1 (IId) potently inhibits wild-type Plasmodium falciparum dihydrofolate reductase (DHFR-TS) with a mean Ki of 2.01 nM and does not inhibit human dihydrofolate reductase at concentrations up to 100,000 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3077918-47-6
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Molecular Weight 1061.99
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Formula C53H60Cl2F2N8O9
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SMILES
O=C(NCCOCCOC1=CC=C(OCCCOC2=C(N=C(N=C2CC)N)N)C(CCC(O)=O)=C1)C3=CC(OC)=C(NC([C@@H]4N[C@@H](CC(C)(C)C)[C@]([C@H]4C5=CC=CC(Cl)=C5F)(C#N)C6=CC=C(Cl)C=C6F)=O)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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