2. Academic Validation
  3. Anticancer indole alkaloids of Rhazya stricta

Anticancer indole alkaloids of Rhazya stricta

  • J Nat Prod. 1981 Nov-Dec;44(6):696-700. doi: 10.1021/np50018a014.
S Mukhopadhyay,  G A Handy,  S Funayama,  G A Cordell
PMID: 7334384 DOI: 10.1021/np50018a014
Abstract

The leaves and roots of Rhazya stricta (Apocynaceae) yielded four Indole Alkaloids. Three of these isolated, vallesiachotamine (1), sewarine (3) and tetrahydrosecamine (4), displayed cytotoxic activity; polyneuridine (2) was not reported previously from this species. Tetrahydrosecaminediol (5), its acetate 6, and didemethoxycarbonyl-tetrahydrosecamine (7) were prepared from tetrahydrosecamine (4) by chemical reactions. The diol 5 was highly cytotoxic.

Figures