2. Academic Validation
  3. Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity induces K562 to differentiate

Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity induces K562 to differentiate

  • Blood. 1993 Dec 15;82(12):3524-9.
M Anafi 1,  A Gazit,  A Zehavi,  Y Ben-Neriah,  A Levitzki
Affiliations

Affiliation

  • 1 Lautenberg Center for Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel.
PMID: 7505115
Abstract

We report on the potency of two Tyrphostin tyrosine kinase blockers, AG 1112 and AG 568, to inhibit p210bcr-abl tyrosine kinase activity in K562 cells, concomitant with the induction of erythroid differentiation. AG 568 and especially AG 1112 represent a specific group of nontoxic protein tyrosine kinase blockers among more than 1,400 tested. These compounds possess therapeutic potential for purging Philadelphia chromosome-positive cells in preparation for autologous bone marrow transplantation in chronic myelogenous leukemia.

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