Tyrphostin AG1112
Tyrphostin AG1112 is a potent inhibitors of CK II. Tyrphostin AG1112 inhibits p210bcr-abl tyrosine kinase, with IC50 values of 2, 15, 20 μM in p210bcr-abl, EGFR and PDGFR cells, respectively.
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- CAS. Nr.: 153150-84-6
- Formel: C15H10N6
- Molecular Weight:274.28
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Tyrphostin AG1112 (0-100 μM) dose-dependently induces differentiation also induce specific growth arrest[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 153150-84-6
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Molecular Weight 274.28
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Formel C15H10N6
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SMILES
N#C/C(C1=NNC(N)=C1C#N)=C\C2=CNC3=C2C=CC=C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. T B Kang, et al. Action of 3 tyrphostin derivatives on casein kinase II from rat liver. Zhongguo Yao Li Xue Bao. 1997 Jan;18(1):56-8. [Content Brief]
[2]. M Anafi, et al. Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity induces K562 to differentiate. Blood. 1993 Dec 15;82(12):3524-9. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Tyrphostin AG1112 Related Classifications
HY-120036 Related Classifications
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