153150-84-6
153150-84-6
Chemical Structure
Tyrphostin AG1112
- CAS No.: 153150-84-6
- Formula:C15H10N6
- Molecular Weight:274.28
IUPAC Name: (Z)-5-amino-3-(1-cyano-2-(1H-indol-3-yl)vinyl)-1H-pyrazole-4-carbonitrile
InChIKey: OJMXHLJIMZMFGX-WEVVVXLNSA-N
SMILES: N#C/C(C1=NNC(N)=C1C#N)=C\C2=CNC3=C2C=CC=C3
Biological Activity: Tyrphostin AG1112 is a potent inhibitors of CK II. Tyrphostin AG1112 inhibits p210bcr-abl tyrosine kinase, with IC50 values of 2, 15, 20 μM in p210bcr-abl, EGFR and PDGFR cells, respectively[1][2].
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Tyrphostin AG1112 | Tyrphostin AG1112 is a potent inhibitors of CK II. Tyrphostin AG1112 inhibits p210bcr-abl tyrosine kinase, with IC50 values of 2, 15, 20 μM in p210bcr-abl, EGFR and PDGFR cells, respectively. | |||||||||||||||||||||
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References
- [1]. T B Kang, et al. Action of 3 tyrphostin derivatives on casein kinase II from rat liver. Zhongguo Yao Li Xue Bao. 1997 Jan;18(1):56-8. [Content Brief]
- [2]. M Anafi, et al. Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity induces K562 to differentiate. Blood. 1993 Dec 15;82(12):3524-9. [Content Brief]
Keywords
