2. Academic Validation
  3. Hypotensive effects of [D-Tyr27,36, D-Thr32]Neuropeptide Y (27-36)

Hypotensive effects of [D-Tyr27,36, D-Thr32]Neuropeptide Y (27-36)

  • Peptides. 1995;16(8):1411-5. doi: 10.1016/0196-9781(95)02039-x.
A K Roscoe 1,  S M Leach,  J W Nyce,  W R Wooles
Affiliations

Affiliation

  • 1 Department of Pharmacology, School of Medicine, East Carolina University, Greenville, NC 27858, USA.
PMID: 8745051 DOI: 10.1016/0196-9781(95)02039-x
Abstract

An analogue of the 10 C-terminal Amino acids of neuropeptide Y (NPY) containing three D-isomeric substitutions (27-36-D) has been synthesized and its cardiovascular activity studied in Sprague-Dawley (SD) and spontaneously hypertensive (SHR) rats. Intravenous administration of 1000 nmol/kg 27-36-D decreases MAP in SHR (-59.9 +/- 5.0 mmHg) and SD rats (-44.4 +/- 4.7 mmHg). The hypotension produced by 1000 nmol/kg 27-36-D diminished by 71.2% following pretreatment with the Histamine Receptor Antagonist diphenhydramine, although histamine depletion with compound 48/80 does not significantly alter this hypotension. These data suggest that NPY (27-36)-D produces a profound and sustained hypotension in two strains of rat which is partially attributable to activity at histamine receptors.

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