2. Antibody-drug Conjugate/ADC Related
  3. Antibody-Drug Conjugates (ADCs)
  4. Mirvetuximab soravtansine

Mirvetuximab soravtansine  (Synonyms: IMGN853)

Cat. No.: HY-132258
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Mirvetuximab soravtansine (IMGN853) is an antibody drug-conjugate (ADC) consisting of the cytotoxic maytansinoid, DM4, covalently linked to the humanized monoclonal antibody M9346A. Mirvetuximab soravtansine selectively binds to folate receptor 1 (FOLR1). Mirvetuximab soravtansine has an anti-proliferative effect via growth arrest and augmented DNA damage.

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Mirvetuximab soravtansine Chemical Structure

Mirvetuximab soravtansine Chemical Structure

CAS No. : 1453084-37-1

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Mirvetuximab soravtansine Related Antibodies

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Description

Mirvetuximab soravtansine (IMGN853) is an antibody drug-conjugate (ADC) consisting of the cytotoxic maytansinoid, DM4, covalently linked to the humanized monoclonal antibody M9346A. Mirvetuximab soravtansine selectively binds to folate receptor 1 (FOLR1). Mirvetuximab soravtansine has an anti-proliferative effect via growth arrest and augmented DNA damage[1].

In Vitro

Mirvetuximab soravtansine (IMGN853; 8 nM; 6 h; IGROV-1 cells) combined with Carboplatin (HY-17393) promotes synergistic growth inhibitory effects and cell cycle perturbations in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mirvetuximab soravtansine Related Antibodies

Cell Cycle Analysis[1]

Cell Line: IGROV-1 cells
Concentration: 8 nM; 20 μM (Carboplatin)
Incubation Time: 6 h
Result: Had almost half of all viable cells accumulating in G2/M.

Western Blot Analysis[1]

Cell Line: IGROV-1 cells
Concentration: 8 nM; 20 μM (Carboplatin)
Incubation Time: 6 h
Result: Induced γH2AX expression in IGROV-1 cells and to levels higher than those seen following carboplatin exposure alone.
In Vivo

Mirvetuximab soravtansine (IMGN853; 5 mg/kg; i.v.; female severe combined immunodeficient (SCID) mice with patient-derived xenografts) potentiates the antitumor activity of Carboplatin in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female severe combined immunodeficient (SCID) mice with patient-derived xenografts[1]
Dosage: 5 mg/kg; 80 mg/kg (Carboplatin)
Administration: Intravenous injection; two consecutive weekly doses
Result: Suppressed tumor growth and combination therapy induced the greatest degree of tumor growth inhibition.
Clinical Trial
Molecular Weight

150000.00

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Mirvetuximab soravtansine]
Shipping

Shipping with dry ice.
Storage

-80°C, protect from light
Purity & Documentation

Purity: 99.90%

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Handling Instructions (2659 KB)
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Mirvetuximab soravtansine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mirvetuximab soravtansine1453084-37-1IMGN853IMGN 853IMGN-853Antibody-Drug Conjugates (ADCs)Antibody-Drug Conjugatesmaytansoid DM4M9346AFOLR1DNA damageIGROV-1 cellsInhibitorinhibitorinhibit

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