2. Cell Cycle/DNA Damage Antibody-drug Conjugate/ADC Related
  3. Antifolate ADC Antibody
  4. Mirvetuximab (powder)

Mirvetuximab (powder)  (Synonyms: M9346A (powder))

Cat. No.: HY-P99225A Purity: 98.87%
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Mirvetuximab (M9346A) (powder) is an anti-FOLR1 (folate receptor 1) monoclonal antibody. Mirvetuximab (powder) is the antibody moiety of folate receptor alpha (FRα)-targeting ADC (Mirvetuximab soravtansine). Mirvetuximab soravtansine can be used in ovarian and other FRα-positive cancer research.

For research use only. We do not sell to patients.

CAS No. : 1453084-36-0

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Mirvetuximab (powder):

Mirvetuximab (powder) Related Antibodies

Top Publications Citing Use of Products
In Vivo Efficacy Study
Bio/Physico-chemical Assay
Histological Imaging/Staining
In Vivo Imaging

    Mirvetuximab (powder) purchased from MedChemExpress. Usage Cited in: Chem Biomed Imaging. 2025 Nov 17;XXXX(XXX).

    Binding affinity experiments of Zr-DFO-Mirvetuximab (2 h) to the FRα protein were performed.

    Mirvetuximab (powder) purchased from MedChemExpress. Usage Cited in: Chem Biomed Imaging. 2025 Nov 17;XXXX(XXX).

    Cell uptake experiments were conducted with Zr-DFO-Mirvetuximab in CAL51 and MDA-MB-231 cells.

    Mirvetuximab (powder) purchased from MedChemExpress. Usage Cited in: Chem Biomed Imaging. 2025 Nov 17;XXXX(XXX).

    Micro-PET/CT imaging of CAL51 and MDA-MB-231 tumor models was performed at 24, 72, 96, 120, and 144 h p.i.

    Mirvetuximab (powder) purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Oct 27:2025.10.27.684721.  [Abstract]

    Relative tumor volume of Mirvetuximab (4.5 mg/kg at Day 0 and Day 7 (i.v)) was measured.

    Mirvetuximab (powder) purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Oct 27:2025.10.27.684721.  [Abstract]

    Histological evaluation of tumor tissues at the study end point was performed by H&E (Magnification 10X (top panel) and 40X (bottom panel); Scale bar: 100µm). Mirvetuximab (4.5 mg/kg at Day 0 and Day 7 (i.v.)) was administered.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Mirvetuximab (M9346A) (powder) is an anti-FOLR1 (folate receptor 1) monoclonal antibody. Mirvetuximab (powder) is the antibody moiety of folate receptor alpha (FRα)-targeting ADC (Mirvetuximab soravtansine). Mirvetuximab soravtansine can be used in ovarian and other FRα-positive cancer research[1][2][3].

    Isotype

    Human IgG1 kappa
    Recommend Isotype Controls
    Species Reactivity

    Human
    In Vitro

    Mirvetuximab (0.17 pM-81 nM, 2 h) (powder) bounds three antibodies bound with high affinity, with EC50 values in the double-digit picomolar range (14.3, 16.5, and 21.1 pM for binding to clones 4E12-G5, 4E12-B9, and 5D12-C11, respectively)[2].
    Mirvetuximab (1 pM-100 nM) (powder) shows dose-dependent binding to folate receptor in the absence of competing anti-idiotype antibodies[2].
    Mirvetuximab (1 pM-100 nM) (powder) associates with H2110 cells with an EC50 of around 650 pM by specific binding of M9346A to surface folate receptor antigen[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Mirvetuximab (powder) Related Antibodies
    Clinical Trial
    Gene ID

    2348  [NCBI]

    Accession
    Application

    ELISA, FACS, Functional assay
    Conjugated

    Unconjugated
    Reconsititution

    The product can be reconstituted/diluted with sterile PBS or saline.
    Molecular Weight

    145.2 kDa

    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    [Mirvetuximab (powder)]
    Shipping

    Shipping with dry ice.
    Formulation

    Please refer to the lot-specific COA for specific buffer information.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Biological Activity
    • Immobilized hu-FRα-ECD-his can bind Mirvetuximab (powder). The EC50 for this effect is 17.26 ng/mL.
    Purity & Documentation

    Purity: 99.31%

    SDS (251 KB)

    COA (232 KB) SDS-PAGE (59 KB) SEC-HPLC (121 KB)

    Inhibitory Antibodies User Guide (603 KB)
    References
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    Mirvetuximab (powder) Related Classifications

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    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Mirvetuximab (powder)1453084-36-0M9346A (powder)AntifolateADC AntibodyFRα-targeting ADCovarianFRα-positive cancerInhibitorinhibitorinhibit

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