1. Cell Cycle/DNA Damage
  2. Antifolate
  3. LSN 3213128

LSN 3213128 

Cat. No.: HY-107981
Handling Instructions

LSN 3213128 is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), with IC50 of 16 nM for AICARFT enzyme inhibiton and 19 nM in cells. Anti-tumor activity.

For research use only. We do not sell to patients.

LSN 3213128 Chemical Structure

LSN 3213128 Chemical Structure

CAS No. : 1941211-99-9

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50 mg USD 2250 Ask For Quote & Lead Time

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Description

LSN 3213128 is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), with IC50 of 16 nM for AICARFT enzyme inhibiton and 19 nM in cells. Anti-tumor activity[1].

IC50 & Target

IC50: 16 nM (AICARFT), 19 nM (AICARFT in cells)[1]

Molecular Weight

409.46

Formula

C₁₇H₁₆FN₃O₄S₂

CAS No.

1941211-99-9

SMILES

O=C1NC=CC2=C1C=C(NS(=O)(C3=CC=C(N4CC[[email protected]@H](O)C4)S3)=O)C(F)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (152.64 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4422 mL 12.2112 mL 24.4224 mL
5 mM 0.4884 mL 2.4422 mL 4.8845 mL
10 mM 0.2442 mL 1.2211 mL 2.4422 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.08 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.08 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

LSN 3213128LSN3213128LSN-3213128AntifolateInhibitorinhibitorinhibit

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Product name:
LSN 3213128
Cat. No.:
HY-107981
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