1. Cell Cycle/DNA Damage
  2. Antifolate
  3. LSN 3213128

LSN 3213128 

Cat. No.: HY-107981
Handling Instructions

LSN 3213128 is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), with IC50 of 16 nM for AICARFT enzyme inhibiton and 19 nM in cells. Anti-tumor activity.

For research use only. We do not sell to patients.

LSN 3213128 Chemical Structure

LSN 3213128 Chemical Structure

CAS No. : 1941211-99-9

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Description

LSN 3213128 is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), with IC50 of 16 nM for AICARFT enzyme inhibiton and 19 nM in cells. Anti-tumor activity[1].

IC50 & Target

IC50: 16 nM (AICARFT), 19 nM (AICARFT in cells)[1]

Molecular Weight

409.46

Formula

C₁₇H₁₆FN₃O₄S₂

CAS No.

1941211-99-9

SMILES

O=C1NC=CC2=C1C=C(NS(=O)(C3=CC=C(N4CC[[email protected]@H](O)C4)S3)=O)C(F)=C2

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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LSN 3213128
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HY-107981
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