1941211-99-9
1941211-99-9
Chemical Structure
LSN 3213128
- CAS No.: 1941211-99-9
- Formula:C17H16FN3O4S2
- Molecular Weight:409.46
IUPAC Name: (R)-N-(6-fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-(3-hydroxypyrrolidin-1-yl)thiophene-2-sulfonamide
InChIKey: DSUZLJDXUJUTGI-LLVKDONJSA-N
SMILES: O=C1NC=CC2=C1C=C(NS(=O)(C3=CC=C(N4CC[C@@H](O)C4)S3)=O)C(F)=C2
Biological Activity: LSN 3213128 is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT) with IC50 of 16 nM. LSN 3213128 exhibits anti-tumor activity[1].
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LSN 3213128 | 98.36% | LSN 3213128 is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT) with IC50 of 16 nM. LSN 3213128 exhibits anti-tumor activity. | ||||||||||||||||||||
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LSN 3213128 (Standard) | LSN 3213128 (Standard) is the analytical standard of LSN 3213128 (HY-107981). This product is intended for research and analytical applications. LSN 3213128 is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT) with IC50 of 16 nM. LSN 3213128 exhibits anti-tumor activity. | |||||||||||||||||||||
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References
- [1]. Fales KR, et al. Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model. J Med Chem. 2017 Dec 14;60(23):9599-9616. [Content Brief]
Keywords
