LSN 3213128 (Standard)
LSN 3213128 (Standard) is the analytical standard of LSN 3213128 (HY-107981). This product is intended for research and analytical applications. LSN 3213128 is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT) with IC50 of 16 nM. LSN 3213128 exhibits anti-tumor activity.
For research use only. We do not sell to patients.
- CAS No.: 1941211-99-9
- Formula: C17H16FN3O4S2
- Molecular Weight:409.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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HY-14518
AminopterinFolic Acid/DHFR Antagonist -
HY-107981
LSN 3213128AICARFT Inhibitor -
HY-13667
Levoleucovorin CalciumAntineoplastic Agent -
HY-10820
Pemetrexed -
HY-17557
Calcium N5-methyltetrahydrofolateFolic Acid Supplement -
HY-13664
Folinic acid calciumBiological Folic Acid -
HY-B0080
Folinic acid calcium salt pentahydrateEndogenous Metabolite -
HY-10446
PralatrexateDihydrofolate Reductasean Inhibitor -
HY-17557R
Calcium N5-methyltetrahydrofolate (Standard)Antifolate Chemical -
HY-14530
PelitrexolGARFT Inhibitor -
HY-17383
Levomefolate calciumFolate Supplement -
HY-10818
LY309887
Biological Activity
Description
IC50 & Target
IC50: 16 nM (AICARFT)[1]
Chemical Information
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CAS No. 1941211-99-9
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Molecular Weight 409.46
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Formula C17H16FN3O4S2
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SMILES
O=C1NC=CC2=C1C=C(NS(=O)(C3=CC=C(N4CC[C@@H](O)C4)S3)=O)C(F)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. Fales KR, et al. Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model. J Med Chem. 2017 Dec 14;60(23):9599-9616. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LSN 3213128 (Standard) Related Classifications
HY-107981R Related Classifications
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