FOLR1 - folate receptor alpha Gene

Homo sapiens

Also known as FBP; FOLR; NCFTD; FRalpha

Gene ID: 2348 | Gene type: protein coding

About FOLR1

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:72,189,709-72,196,323 (from NCBI)

This gene has 5 transcripts (splice variants), 222 orthologues, 4 paralogues and is associated with 3 phenotypes. Biased expression in lung (RPKM 83.5), kidney (RPKM 59.8) and 4 other tissues.

Summary

The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]

FOLR1 Products(4)

mRNA	Protein	Name
NM_000802.3	NP_000793.1	folate receptor alpha precursor
NM_016724.3	NP_057936.1	folate receptor alpha precursor
NM_016725.3	NP_057937.1	folate receptor alpha precursor
NM_016729.3	NP_057941.1	folate receptor alpha precursor

FOLR1 Protein Structure

Folate_rec

0
100
200
257 a.a.

Protein Preferred Names

Protein Names

folate receptor alpha

FR-alpha

Recombinant FOLR1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70296	FOLR1 Protein, Human (210a.a, HEK293, His)	P15328 (R25-S234)	≥95%
HY-P72371	FOLR1 Protein, Human (Biotinylated, HEK293, His-Avi)	P15328 (R25-S234)	≥95%
HY-P75774	FOLR1 Protein, Human (209a.a, HEK293, His)	P15328/NP_057937.1 (R25-M233)	≥95%
HY-P78445	FOLR1 Protein, Human (HEK293, His-Avi)	P15328 (R25-M233)	≥95%

Related Diseases

Diseases

Alias

Neurodegeneration Due To Cerebral Folate Transport Deficiency

Cerebral Folate Transport Deficiency	Cerebral Folate Deficiency
NCFTD	Cerebral Folate Deficiency Syndrome
Folr1 Deficiency	Neurodegenerative Syndrome Due To Cerebral Folate Transport Deficiency

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Myelomeningocele

Meningomyelocele

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Choriocarcinoma Of The Testis

Testicular Choriocarcinoma

Anencephaly

Aprosencephaly	Anencephalus
Congenital Absence Of Brain	Absence Of A Large Part Of The Brain And The Skull
Anencephalia	Anencephalic Monster
Brain Absence	Brain Agenesis
Brain Aplasia	Absent Brain
Anencephalic	Congenital Absence Of Cerebrum
Congenital Hemicrania	Incomplete Anencephaly

Folate Malabsorption, Hereditary

Hereditary Folate Malabsorption	Congenital Defect Of Folate Absorption
Congenital Folate Malabsorption	Folic Acid Transport Defect
HFM

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Fallopian Tube Adenocarcinoma

Adenocarcinoma Of The Fallopian Tube

Leukodystrophy

Leukodystrophies

Serine Deficiency

Charcot-Marie-Tooth Disease, Axonal, Type 2dd

CMT2DD	Charcot-Marie-Tooth Neuropathy, Type 2dd
Charcot-Marie-Tooth Disease Type 2dd	Atp1a1-Related Autosomal Dominant Charcot-Marie-Tooth Disease Type 2
Atp1a1-Related Cmt2	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2dd
Charcot-Marie-Tooth Disease 2dd

Epilepsy, Pyridoxine-Dependent

Pyridoxine-Dependent Epilepsy	PDE
Pyridoxine Dependency With Seizures	Vitamin B6-Dependent Seizures
EPD	Aasa Dehydrogenase Deficiency
Antiquitin Deficiency	Pyridoxine Dependency
Glutamate Decarboxylase Deficiency	Pyridoxine-Dependent Seizures
Deficiency Of Glutamate Decarboxylase

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-132258A	Mirvetuximab soravtansine (solution)		98.20%	Phase 2
HY-132258	Mirvetuximab soravtansine		99.90%	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99225	Mirvetuximab		99.76%	Phase 3

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05029	FOLR1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FOLR1	VGNC	VGNC:102889
Macaca mulatta	FOLR1	VGNC	VGNC:72689
Rattus norvegicus	FOLR1	RGD	RGD:71032
Mus musculus	FOLR1	MGD	MGI:95568
Canis familiaris	FOLR1	NCBI
Macaca fascicularis	FOLR1	NCBI
Others	FOLR1	NCBI

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