2. Cell Cycle/DNA Damage
  3. Folate Receptor (FR)
  4. KHK2805

KHK2805  (Synonyms: RA15-7, HuRA15-7Acc)

Cat. No.: HY-P992004
Technical Support

KHK2805 (RA15-7) is a humanized antibody against folate receptor α (FOLR1), with a Kd of 0.647 nM for human FOLR1. KHK2805 binds to a unique epitope of FOLR1 and mediates antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity against FOLR1-expressing cells. KHK2805 exhibits cytotoxicity against both ovarian cancer cells and Platinum (HY-W096169D)-resistant ovarian cancer cells. KHK2805 can be used for the research of tumors such as ovarian cancer.

For research use only. We do not sell to patients.

KHK2805

KHK2805 Chemical Structure

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KHK2805 Related Antibodies

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Description

KHK2805 (RA15-7) is a humanized antibody against folate receptor α (FOLR1), with a Kd of 0.647 nM for human FOLR1. KHK2805 binds to a unique epitope of FOLR1 and mediates antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity against FOLR1-expressing cells. KHK2805 exhibits cytotoxicity against both ovarian cancer cells and Platinum (HY-W096169D)-resistant ovarian cancer cells. KHK2805 can be used for the research of tumors such as ovarian cancer[1].

Species Reactivity

Human
In Vitro

KHK2805 (10 μg/mL; 1 h) binds strongly to the FOLR1-expressing human ovarian cancer cell lines IGROV1, OVMANA, SKOV3 and OVCAR3[1].
KHK2805 (0.1-10000 ng/mL; 2 h) induces complement-dependent cytotoxicity (CDC) against FOLR1-expressing human ovarian cancer cell lines IGROV1 and OVMANA[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KHK2805 Related Antibodies
In Vivo

KHK2805 (0.1-10 mg/kg; i.v.; twice/once a week) significantly reduces intraperitoneal tumor burden and ascites volume in SCID mice with peritoneal dissemination of Platinum (HY-W096169D)-resistant ovarian cancer[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID mice (C.B-17/Icr-scid/scid Jcl, female, 6 weeks old, Platinum (HY-W096169D)-resistant peritoneal dissemination and malignant ascites model induced by intraperitoneal inoculation of IGROV1 cells)[1]
Dosage: 0.1 mg/kg; 1 mg/kg; 10 mg/kg
Administration: i.v.; twice a week; once a week
Result: Significantly reduced intraperitoneal tumor burden and eliminated detectable malignant ascites (10 mg/kg, twice a week).
Significantly reduced both intraperitoneal tumor burden and ascites volume (1 mg/kg, once a week).
Reduced tumor burden and ascites volume, with no statistically significant effects (0.1 mg/kg, once a week).
Significantly prolonged median survival.
Gene ID

2348  [NCBI]

Accession
Target

FOLR1/FRA
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
SMILES

[KHK2805]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KHK2805 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KHK2805RA15-7, HuRA15-7AccKHK 2805KHK-2805Folate Receptor (FR)FOLR3CDCADCCovarian cancer cellsSKOV3SCID miceplatinum-resistant ovarian cancer cellsFOLR1IGROV1FOLR2Inhibitorinhibitorinhibit

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