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SLC35F6 - solute carrier family 35 member F6 Gene

Also Known as ANT2BP; TANGO9; C2orf18

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54978

About SLC35F6

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:26,764,284-26,781,231 (from NCBI)

This gene has 4 transcripts (splice variants) and 195 orthologues. Ubiquitous expression in thyroid (RPKM 11.5), skin (RPKM 10.8) and 25 other tissues.

Summary

Predicted to enable transmembrane transporter activity. Involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway and positive regulation of cell population proliferation. Located in several cellular components, including lysosomal membrane; mitochondrion; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SLC35F6 Products (1)

mRNA	Protein	Name
NM_017877.4	NP_060347.2	solute carrier family 35 member F6 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19154410	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	19154410	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19154410	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in lysosomal membrane	IDA IDA: Inferred from direct assay	20957757	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	19154410	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC35F6 Protein Structure

SLC35F

0
100
200
300
371 a.a.

Protein Preferred Names	Protein Names
solute carrier family 35 member F6	ANT2-binding protein

SLC35F6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLC35F6	Q8N357	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	SLC35F6	Q8N357	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	SLC35F6	Q8N357	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	SLC35F6	Q8N357	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	SLC35F6	Q8N357	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	SLC35F6	Q8N357	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	SLC35F6	Q8N357	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	SLC35F6	Q8N357	CBARP	Homo sapiens	Q8N350-4	Y2H Array	32296183
Intra	SLC35F6	Q8N357	CBARP	Homo sapiens	Q8N350-4	Y2H Prey Pooling	32296183
Intra	SLC35F6	Q8N357	FOLR1	Homo sapiens	P15328	Y2H Prey Pooling	32296183
Intra	SLC35F6	Q8N357	FOLR1	Homo sapiens	P15328	Y2H Array	32296183
Intra	SLC35F6	Q8N357	CERS4	Homo sapiens	Q9HA82	Y2H Prey Pooling	32296183
Intra	SLC35F6	Q8N357	CERS4	Homo sapiens	Q9HA82	Validated Y2H	32296183
Intra	SLC35F6	Q8N357	CERS4	Homo sapiens	Q9HA82	Y2H Array	32296183
Intra	SLC35F6	Q8N357	TIMMDC1	Homo sapiens	Q9NPL8	Y2H Prey Pooling	32296183
Intra	SLC35F6	Q8N357	TIMMDC1	Homo sapiens	Q9NPL8	Validated Y2H	32296183
Intra	SLC35F6	Q8N357	TIMMDC1	Homo sapiens	Q9NPL8	Y2H Array	32296183
Intra	SLC35F6	Q8N357	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	SLC35F6	Q8N357	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	SLC35F6	Q8N357	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Pancreatic Ductal Adenocarcinoma	Ductal Adenocarcinoma Of The Pancreas
Gingival Fibromatosis	Hereditary Gingival Fibromatosis Hereditary Gingival Hyperplasia Autosomal Dominant Gingival Fibromatosis Autosomal Dominant Gingival Hyperplasia Fibromatosis, Gingival, Hereditary Fibromatosis, Gingival
Mitochondrial Complex I Deficiency, Nuclear Type 1	Mitochondrial Complex I Deficiency Nadh:Q(1) Oxidoreductase Deficiency MC1DN1 Nadh-Coenzyme Q Reductase Deficiency Isolated Mitochondrial Respiratory Chain Complex I Deficiency Isolated Nadh-Coenzyme Q Reductase Deficiency Isolated Nadh-Coq Reductase Deficiency Isolated Nadh-Ubiquinone Reductase Deficiency Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of Nuclear Type Mitochondrial Complex I Deficiency 1 Isolated Complex I Deficiency Complex 1 Mitochondrial Respiratory Chain Deficiency Nadh Coenzyme Q Reductase Deficiency Complex I Mitochondrial Respiratory Chain Deficiency Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I Nadh:Ubiquinone Oxidoreductase Deficiency Complex I, Mitochondrial Respiratory Chain, Deficiency Of

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13209	SLC35F6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC35F6	RGD	RGD:1309228
Macaca mulatta	SLC35F6	VGNC	VGNC:106219
Felis catus	SLC35F6	VGNC	VGNC:65336
Bos taurus	SLC35F6	VGNC	VGNC:34836
Canis familiaris	SLC35F6	VGNC	VGNC:46380
Mus musculus	SLC35F6	MGD	MGI:1922169
Others	SLC35F6	NCBI