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Rinatabart

(Synonyms: F131; GEN1184 antibody)
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Rinatabart (F131) is an IgG1-κ human antibody targeting FOLR1, with its corresponding isotype control being Human IgG1 kappa, Isotype Control (HY-P99001). The Fc region of Rinatabart is engineered to reduce antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) activities. The KD values of Rinatabart binding to human FOLR1 in two sets of BLI assays are 1.528 nM and 5.296 nM, respectively. Rinatabart shows significantly lower affinity for FOLR2 and mouse FOLR1, and no reliable specific binding to FOLR3 and rat FOLR1. Rinatabart can be used in studies of FOLR1 targeting and antibody-drug conjugates.

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  • Pureté: 99.47%
  • CAS No.: 2853518-94-0
  • Masse moléculaire:145.2 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Rinatabart
  • Experimental Validation Results for Rinatabart
  • Experimental Validation Results for Rinatabart
  • Rinatabart Chemical Structure
    Rinatabart Chemical Structure
CAS No.: 2853518-94-0
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Rinatabart Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    IgG1-kappa

  • 1/16

    Immobilized Human FOLR1, His Tag can bind Rinatabart. The EC50 for this effect is 8.83 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 MCF-7 cells with Rinatabart (HY-P990941, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Rinatabart Chemical Structure
    1/16
  • Rinatabart
  • Immobilized Human FOLR1, His Tag can bind Rinatabart. The EC50 for this effect is 8.83 ng/mL.
  • Flow cytometric analysis of 1X106 MCF-7 cells with Rinatabart (HY-P990941, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • IgG1-kappa