Folate Binding Protein Antibody (YA3809)(PBS only)

Cat. No.: HY-P84112A: Ficha de datos User Guide for Antibodies
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Folate Binding Protein Antibody (YA3809) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Folate Binding Protein.

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Tamaño		Stock
50 μL		Obtener un presupuesto
100 μL		Obtener un presupuesto

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn

Descripciòn

Folate Binding Protein Antibody (YA3809) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Folate Binding Protein.

Host

Mouse

Peso molecular

Predicted band size: 30 kDa;

Observed band size: 40 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

P15328

Gene ID

2348 [NCBI]

Immunogen

Purified recombinant fragment of human FOLR1 (AA: 41-227) expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:1000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-1:500
FC FC: Flow Cytometry	1:200-1:400
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Pureza	affinity purified.	Conjugation	Non-conjugated
Isotype	IgG2a

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells (PubMed:19074442, PubMed:23851396, PubMed:23934049, PubMed:2527252, PubMed:8033114, PubMed:8567728). Has high affinity for folate and folic acid analogs at neutral pH (PubMed:23851396, PubMed:23934049, PubMed:2527252, PubMed:8033114, PubMed:8567728). Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (PubMed:8567728). Required for normal embryonic development and normal cell proliferation (By similarity)

Subcellular Localization：Cell membrane; Lipid-anchor, GPI-anchor; Apical cell membrane; Lipid-anchor, GPI-anchor; Basolateral cell membrane; Lipid-anchor, GPI-like-anchor; Secreted; Cytoplasmic vesicle; Cytoplasmic vesicle, clathrin-coated vesicle; Endosome

Expression：
Tissue_specificity:It is primarily expressed in epithelial tissues. Expression increases in malignant tissues. It is expressed in the kidneys, lungs, and cerebellum. It can also be detected in the placental and thymic epithelium.

Synonyms

FBP; FOLR

Documentación

User Guide for Antibodies (1077 KB)