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  3. Antibiotic
  4. Farletuzumab

Farletuzumab  (Synonyms: MORAb-003)

Cat. No.: HY-P99153 Purity: 99.00%
COA

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Farletuzumab (MORAb-003) is a potent folate receptor-alpha (FRα) inhibitor. Farletuzumab is a humanized monoclonal antibody with high affinity for FRα. Farletuzumab possesses growth-inhibitory functions on cells overexpressing FRα. Farletuzumab can be used in research of cancer.

For research use only. We do not sell to patients.

Farletuzumab Chemical Structure

Farletuzumab Chemical Structure

CAS No. : 896723-44-7

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Description

Farletuzumab (MORAb-003) is a potent folate receptor-alpha (FRα) inhibitor. Farletuzumab is a humanized monoclonal antibody with high affinity for FRα. Farletuzumab possesses growth-inhibitory functions on cells overexpressing FRα. Farletuzumab can be used in research of cancer[1].

In Vitro

Farletuzumab (MORAb-003; 0-10 µg/mL; CHO-FR cells) inhibits FRα-dependent cell growth and increases folate EC50 in a dose-dependent manner[1].
Farletuzumab (0.1-100 µg/mL; IGROV-1 cells; 1 h) mediates tumor cytotoxicity via complement dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC) in vitro[1].
Farletuzumab (0-10 µg/mL; CHO-FR cells) inhibits phosphorylation of proteins by Lyn kinase, a member of the src family of kinases, thereby, blocking a FRa-mediated signaling pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Farletuzumab Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: IGROV-1 cells
Concentration: 0.1, 1, 10, and 100 µg/mL
Incubation Time: 1 hours
Result: Had significant cytotoxicity at IGROV-1 cells.
Clinical Trial
Molecular Weight

145360.00

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Farletuzumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.00%

COA (291 KB)

Handling Instructions (2659 KB)
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Farletuzumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Farletuzumab896723-44-7MORAb-003MORAb003MORAb 003Antibiotichumanized monoclonal antibodyfolate receptor-alphaanticancerCHO-FR cellsIGROV-1 cellsInhibitorinhibitorinhibit

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