2. GPCR/G Protein Neuronal Signaling
  3. Orexin Receptor (OX Receptor)
  4. MK-8133

MK-8133 is an orexin-2 receptor antagonist. MK-8133 can be used in the study of insomnia.

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MK-8133

MK-8133 화학구조

CAS No. : 1431472-56-8

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MK-8133 Related Antibodies

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OX2 Receptor OX1 Receptor

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제품 설명

MK-8133 is an orexin-2 receptor antagonist. MK-8133 can be used in the study of insomnia[1].

IC50 & Target

OX2 Receptor

 

Cellular Effect
Cell Line Type Value Description References
CHO-K1 IC50
28 1
Compound: 6b
Antagonist activity against human OX2R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intercellular Ca2+ mobilization by FLIPR assay
Antagonist activity against human OX2R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intercellular Ca2+ mobilization by FLIPR assay
[PMID: 25981685]
CHO-K1 IC50
28 1
Compound: 6b
Antagonist activity against human OX2R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intercellular Ca2+ mobilization by FLIPR assay
Antagonist activity against human OX2R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intercellular Ca2+ mobilization by FLIPR assay
[PMID: 25981685]
CHO-K1 IC50
28 1
Compound: 6b
Antagonist activity against human OX2R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intercellular Ca2+ mobilization by FLIPR assay
Antagonist activity against human OX2R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intercellular Ca2+ mobilization by FLIPR assay
[PMID: 25981685]
CHO-K1 IC50
4900 1
Compound: 6b
Antagonist activity against human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intercellular Ca2+ mobilization by FLIPR assay
Antagonist activity against human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intercellular Ca2+ mobilization by FLIPR assay
[PMID: 25981685]
CHO-K1 IC50
4900 1
Compound: 6b
Antagonist activity against human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intercellular Ca2+ mobilization by FLIPR assay
Antagonist activity against human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intercellular Ca2+ mobilization by FLIPR assay
[PMID: 25981685]
CHO-K1 IC50
4900 1
Compound: 6b
Antagonist activity against human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intercellular Ca2+ mobilization by FLIPR assay
Antagonist activity against human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intercellular Ca2+ mobilization by FLIPR assay
[PMID: 25981685]
분자량

399.45

화학식

C23H21N5O2
CAS No.
SMILES

N#CC1=CC(O[C@H]2CN(C(C3=CC=CC=C3C4=NC=CC=N4)=O)[C@H](C)CC2)=NC=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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MK-8133 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MK-81331431472-56-8MK8133MK 8133Orexin Receptor (OX Receptor)Hypocretin ReceptorHCRT ReceptorGPCRInsomniaOrexinSleepInhibitorinhibitorinhibit

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상품명:
MK-8133
Cat. No.:
HY-123737
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