MtInhA-IN-1

製品番号: HY-151941: Data Sheet 取扱説明書
FAQs
Technical Support

MtInhA-IN-1 is a selective and orally active Mycobacterium tuberculosis NADH-dependent enoyl-acyl carrier protein reductase (MtInhA) inhibitor with an IC₅₀ of 0.23 μM. MtInhA-IN-1 potently against M. tuberculosis H37Rv strain with a MIC value of 0.4 μM.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

MtInhA-IN-1 構造式

CAS 番号 : 3037822-97-9

容量		在庫状況
MOQ		Minimum order quantity
50 mg		お問い合わせ
100 mg		お問い合わせ
250 mg		お問い合わせ
Other size		お問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

おすすめ

•関連小分子:

•関連タンパク質:

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target

IC50: 0.23 μM (Mycobacterium tuberculosis NADH-dependent enoyl-acyl carrier protein reductase (MtInhA))^[1]
MIC: 0.4 μM (M. tuberculosis H37Rv strain), 0.1 μM (M. tuberculosis strains PT2), 0.2 μM (M. tuberculosis strains PT12), and 0.1 μM (M. tuberculosis strains PT20)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	CC₅₀	18.3 3 Compound: 19k	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by neutral red uptake assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by neutral red uptake assay	[PMID: 36435016]
HepG2	CC₅₀	>20 3 Compound: 19k	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36435016]
HepG2	CC₅₀	18.3 3 Compound: 19k	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by neutral red uptake assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by neutral red uptake assay	[PMID: 36435016]
HepG2	CC₅₀	> 20 3 Compound: 19k	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36435016]
Vero	CC₅₀	>20 3 Compound: 19k	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36435016]
Vero	CC₅₀	12.2 3 Compound: 19k	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by neutral red uptake assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by neutral red uptake assay	[PMID: 36435016]
Vero	CC₅₀	12.2 3 Compound: 19k	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by neutral red uptake assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by neutral red uptake assay	[PMID: 36435016]
Vero	CC₅₀	> 20 3 Compound: 19k	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36435016]

体外実験

MtInhA-IN-1 (compound 19k) shows inhibitory activity against a panel of multidrug-resistant M. tuberculosis strains, M. tuberculosis strains PT2, PT12, and PT20. The MIC values of 0.1 μM, 0.2 μM, and 0.1 μM for PT2, PT12, and PT20, respectively. In addition, MtInhA-IN-1 has low cytotoxicity against HepG2 and Vero cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

MtInhA-IN-1 (compound 19k; 300-450 μM/kg; p.o; daily; for 14 days) shows bacteriostatic effect in a murine model of tuberculosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	M. tuberculosis-infected mice ^[1]
Dosage:	300 μM/kg and 450 μM/kg
Administration:	Oral administration; daily; for 14 days
Result:	Reduced the growth of bacilli in the lungs of mice.

分子量

396.32

分子式

C₂₁H₂₂BrN₃

CAS 番号

3037822-97-9

SMILES

CC1=NC2=C(C(NC3=CC=C(C=C3)N4CCCCC4)=C1)C=C(C=C2)Br

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Josiane Delgado Paz, et al. Novel 4-aminoquinolines: Synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase, antitubercular activity, SAR, and preclinical evaluation. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114908. [Content Brief]

MtInhA-IN-1 Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MtInhA-IN-13037822-97-9BacterialMtInhA inhibitorMycobacterium tuberculosisorally active4-aminoquinolinesInhibitorinhibitorinhibit

最近チェックした製品:

製品名

カスタマ需要量 *

お名前 *

タイトル

メールアドレス *

電話番号 *

デパートメント

組纖名 *

市区町村

都道府県

国或いは地域 *

必ず会社名を記載ください。個人への返信は行いません。

備考

製品名

Lot #