Myostatin inhibitory peptide 2

Cat. No.: HY-P10476 Pureté: 99.75%: Fiche technique
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Myostatin inhibitory peptide 2 (compd 2) is a myostatin inhibitor with a K_d of 35.9 nM. Myostatin inhibitory peptide 2 can be used for researches of muscle atrophic disorders.

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Myostatin inhibitory peptide 2 Chemical Structure

CAS No. : 1621169-52-5

Size	Stock	Quantité
1 mg	En stock	Estimated Time of Arrival: December 31
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
50 mg	Obtenir un devis
100 mg	Obtenir un devis

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Other Forms of Myostatin inhibitory peptide 2:

Myostatin inhibitory peptide 2 TFA Obtenir un devis

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Activité biologique
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Description

Myostatin inhibitory peptide 2 (compd 2) is a myostatin inhibitor with a K_d of 35.9 nM. Myostatin inhibitory peptide 2 can be used for researches of muscle atrophic disorders^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	4.1 3 Compound: 2	Inhibition of human recombinant myostatin pre-incubated with compound for 1 hr before addition to human HepG2 cells assessed as reduction in myostatin-mediated downstream transcriptional response by myostatin-responsive (CAGA)12-luciferase reporter gene a Inhibition of human recombinant myostatin pre-incubated with compound for 1 hr before addition to human HepG2 cells assessed as reduction in myostatin-mediated downstream transcriptional response by myostatin-responsive (CAGA)12-luciferase reporter gene a	[PMID: 25569186]

In Vivo

Myostatin inhibitory peptide 2 (0.75 mM, 40 μL, i.m., once every two weeks for 4 weeks) increases the muscle weight of skeletal muscles in muscular dystrophy model mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Masse moléculaire

2956.49

Formule

C₁₃₃H₂₂₇N₄₃O₃₃

CAS No.

1621169-52-5

Appearance

Solid

Color

White to off-white

Sequence

Ala-Trp-Arg-Gln-Asn-Thr-Arg-Tyr-Ser-Arg-Ile-Glu-Ala-Ile-Lys-Ile-Gln-Ile-Leu-Ser-Lys-Leu-Arg-Leu-NH2

Sequence Shortening

AWRQNTRYSRIEAIKIQILSKLRL-NH2

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvant et solubilité

In Vitro:

H₂O : ≥ 25 mg/mL (8.46 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.3382 mL	1.6912 mL	3.3824 mL
5 mM	0.0676 mL	0.3382 mL	0.6765 mL
10 mM	---	---	---

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculateur de molarité
Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureté et documentation

Purity: 99.75%

Select Batch:

Fiche technique (276 KB) SDS (252 KB)

COA (253 KB) RP-HPLC (254 KB) MS (235 KB) Elemental Analysis Report (111 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Takayama K, et al. Identification of the minimum peptide from mouse myostatin prodomain for human myostatin inhibition. J Med Chem. 2015 Feb 12;58(3):1544-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.3382 mL	1.6912 mL	3.3824 mL	8.4560 mL
H₂O	5 mM	0.0676 mL	0.3382 mL	0.6765 mL	1.6912 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.