nAChR agonist CMPI hydrochloride

Cat. No.: HY-136258: Ficha de datos Instrucciones de manejo
FAQs
Technical Support

nAChR agonist CMPI hydrochloride is a potent and selective positive allosteric modulator (PAM) of nAChR containing a α4:α4 subunit interface. nAChR agonist CMPI hydrochloride enhances the response of (α4)₃(β2)₂ nAChR to ACh (10 µM) with an EC₅₀ of 0.26 µM. nAChR agonist CMPI hydrochloride has potential for the research of nicotine dependence and many neuropsychiatric conditions associated with decreased brain cholinergic activity.

Para uso exclusivo en investigación. No vendemos a pacientes.

nAChR agonist CMPI hydrochloride Estructura química

No. CAS : 2250025-94-4

Tamaño	Stock	Cantidad
5 mg	Obtener un presupuesto 2 - 3 weeks 4 - 5 weeks 5 - 6 weeks 1 - 2 weeks	Estimated Time of Arrival: December 31
10 mg	Obtener un presupuesto 2 - 3 weeks 4 - 5 weeks 5 - 6 weeks 1 - 2 weeks	Estimated Time of Arrival: December 31
50 mg	Obtener un presupuesto
100 mg	Obtener un presupuesto

Synthetic products have potential research and development risk.

or Consulta para venta a granel

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Revisión del cliente

Based on 1 Customer Validation

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn	nAChR agonist CMPI hydrochloride is a potent and selective positive allosteric modulator (PAM) of nAChR containing a α4:α4 subunit interface. nAChR agonist CMPI hydrochloride enhances the response of (α4)₃(β2)₂ nAChR to ACh (10 µM) with an EC₅₀ of 0.26 µM. nAChR agonist CMPI hydrochloride has potential for the research of nicotine dependence and many neuropsychiatric conditions associated with decreased brain cholinergic activity^[1]^[2].
IC₅₀ & Target	nAChR^[1]
In Vitro	CMPI (0.01-10 µM) potentiates (α4)₃(β2)₂ (low ACh sensitivity) but not (α4)₂(β2)₃ (high ACh sensitivity) nAChRs in Xenopus laevis oocytes^[1]. CMPI (0.01-10 µM) inhibits (α4)₂(β2)₃, human muscle and Torpedo nAChRs with IC₅₀s of 0.6, 0.7 and 0.2 µM, respectively in Xenopus oocytes^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. nAChR agonist CMPI hydrochloride Related Antibodies
Peso molecular	379.28
Fòrmula	C₁₈H₂₀Cl₂N₄O
No. CAS	2250025-94-4
SMILES	CC1=C(C2=CC(C3=CC=CC=C3Cl)=NO2)C=NN1C4CCNCC4.[H]Cl
Envío	Room temperature in continental US; may vary elsewhere.
Almacenamiento	Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación	Ficha de datos (270 KB) Instrucciones de manejo (2659 KB)
Referencias	[1]. Hamouda AK, et, al. Photolabeling a Nicotinic Acetylcholine Receptor (nAChR) with an (α4)3(β2)2 nAChR-Selective Positive Allosteric Modulator. Mol Pharmacol. 2016 May;89(5):575-84. [Content Brief] [2]. Wang ZJ, et, al. Unraveling amino acid residues critical for allosteric potentiation of (α4)3(β2)2-type nicotinic acetylcholine receptor responses. J Biol Chem. 2017 Jun 16;292(24):9988-10001. [Content Brief]