Kinase, Natto fermentation

Name: Kinase, Natto fermentation
Brand: MedChemExpress
SKU: HY-P2373
Rating: 5.0 (4 reviews)

製品番号: HY-P2373: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

Kinase, Natto fermentation is a potent fibrinolytic enzyme. Kinase, Natto fermentation can break down blood clots by directly hydrolyzing fibrin and plasmin substrate. Kinase, Natto fermentation can be used for the research of cardiovascular diseases.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 133876-92-3

容量	価格（税別）	在庫状況	数量
5 mg	$90	在庫あり	Estimated Time of Arrival: December 31
10 mg	$150	在庫あり	Estimated Time of Arrival: December 31
25 mg	$258	在庫あり	Estimated Time of Arrival: December 31
50 mg	$400	在庫あり	Estimated Time of Arrival: December 31
100 mg	$680	在庫あり	Estimated Time of Arrival: December 31
200 mg	$940	在庫あり	Estimated Time of Arrival: December 31
500 mg		お問い合わせ
1 g		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 4 publication(s) in Google Scholar

顧客検証

Cell Proliferation/Viability Assay

: Kinase, Natto fermentation purchased from MedChemExpress. Usage Cited in: J Dent Sci. 2025 Nov 1.; Cells were exposed to different concentrations of nattokinase for various durations, after which cell viability was measured.

: Kinase, Natto fermentation purchased from MedChemExpress. Usage Cited in: J Dent Sci. 2025 Nov 1.; Cells were pretreated with Kinase, Natto fermentation for 1 hour, then exposed to PM, and then (B) COX-2 protein expression was detected.

: Kinase, Natto fermentation purchased from MedChemExpress. Usage Cited in: J Dent Sci. 2025 Nov 1.; Cells were pretreated with NAC, APO, DPI, or natto kinase (Natto fermentation) for 1 hour, then exposed to PM, and Akt phosphorylation was detected.

おすすめ

•関連小分子:

•関連タンパク質:

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

体外実験

Kinase, Natto fermentation dissolves 94% blood clot at ten minutes and degrades the fibrin clot after two hours of incubation^[2].
Product Information
Molecular weight: 27728 Da (a single-chain polypeptide enzyme composed of 275 amino acids in a fixed arrangement) Acidity and alkalinity: relatively stable in neutral or alkaline environment (pH 7.0 ~12.0), extremely unstable when pH <5.0. However, the stability of nattokinase is greatly improved after mixing with boiled rice extract, broth, serum protein and gastric juice protein, and the enzyme activity will not be completely lost even under acidic conditions.
Temperature: sensitive to high temperature, with better stability below 37°C, and it will be quickly inactivated due to protein denaturation when the temperature is higher than 60°C. Freeze-thaw: After repeated freeze-thaw cycles for 5 times, 95% of the original activity can still be retained.

Instructions

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Kinase, Natto fermentation (150-250 mg/kg; oral gavage twice daily for 2 days) exhibits fibrinolytic activity and dissolves blood clots in vivo^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sprague-Dawley (SD) rats (180-220 g) are injected κ-Carrageenan^[3]
Dosage:	150, 250 mg/kg
Administration:	Oral gavage twice daily for 2 days
Result:	Increased the plasma concentration of fibrin/fibrinogen degradation products (FDPs) and D-Dimer in a dose-dependent manner. Decreased the fraction of the vessel cross section occupied by thrombosis.

CAS 番号

133876-92-3

Appearance

Solid

Color

White to off-white

SMILES

[Kinase, Natto fermentation]

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

溶剤 & 溶解度

体外:

H₂O : 100 mg/mL (Need ultrasonic)

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL; Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

Select Batch:

データシート (270 KB) SDS (251 KB)

COA (230 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Weng Y, et, al. Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease. Int J Mol Sci. 2017 Feb 28; 18(3):523. [Content Brief]

[2]. Chandrasekaran SD, et, al. Exploring the In Vitro Thrombolytic Activity of Nattokinase From a New Strain Pseudomonas aeruginosa CMSS. Jundishapur J Microbiol. 2015 Oct 26; 8(10): e23567. [Content Brief]

[3]. Xu J, et, al. Thrombolytic effects in vivo of nattokinase in a carrageenan-induced rat model of thrombosis. Acta Haematol. 2014; 132(2): 247-53. [Content Brief]