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NF-κΒ activator 2 

Cat. No.: HY-134477
Handling Instructions

NF-κΒ activator 2 is a potent and orally active NF-ҡB activator, with an EC50 of 1.58 μM. NF-κΒ activator 2 induces SOD2 through increasing NF-ҡB expression and activation. NF-κΒ activator 2 can be used for the research of amyotrophic lateral sclerosis (ALS).

For research use only. We do not sell to patients.

NF-κΒ activator 2 Chemical Structure

NF-κΒ activator 2 Chemical Structure

CAS No. : 2375281-44-8

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Description

NF-κΒ activator 2 is a potent and orally active NF-ҡB activator, with an EC50 of 1.58 μM. NF-κΒ activator 2 induces SOD2 through increasing NF-ҡB expression and activation. NF-κΒ activator 2 can be used for the research of amyotrophic lateral sclerosis (ALS)[1].

IC50 & Target[1]

NF-κB

1.58 μM (EC50)

In Vitro

NF-κΒ activator 2 (compound 61) (1 μM, 6 h) induces SOD2 mRNA expression in SH-SY5Y neuroblastoma cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NF-κΒ activator 2 (1 mg/kg; i.v.) displays a suitable half-life (0.96 h) in mice[1].
NF-κΒ activator 2 (5 mg/kg; p.o.) displays a comparable half-life (2.86 h), oral bioavailability (15.6%), and Cmax (92 ng/mL)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

298.27

Formula

C₁₆H₁₁FN₂O₃

CAS No.

2375281-44-8

SMILES

O=C(O)C1=CC=CC(C2=CN=C(NC3=CC=CC=C3F)O2)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

NF-κΒ activator 2NF-κBNuclear factor-κBNuclear factor-kappaBNF-?BSOD2amyotrophiclateralsclerosisALSInhibitorinhibitorinhibit

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NF-κΒ activator 2
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HY-134477
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