2. Membrane Transporter/Ion Channel
  3. P2X Receptor
  4. NF023 hexasodium

NF023 (hexasodium)  (Synonyms: NF 023 水和物)

製品番号: HY-108676 純度: 99.99%
COA 取扱説明書 Technical Support

NF023 hexasodium is a selective and competitive P2X1 receptor antagonist, with IC50 values of 0.21 μM, 28.9 μM, > 50 μM and > 100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively.

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NF023 hexasodium

NF023 (hexasodium) 構造式

CAS 番号 : 104869-31-0

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 1535 在庫あり
Solution
10 mM * 1 mL in Water USD 1535 在庫あり
Solid
1 mg $295 在庫あり
5 mg $600 在庫あり
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Based on 1 publication(s) in Google Scholar

Other Forms of NF023 hexasodium:

  • NF023 お問い合わせ

NF023 (hexasodium) 関連抗体

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P2X Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
P2X1 Receptor P2X2 Receptor P2X3 Receptor P2X4 Receptor P2X7 Receptor

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製品説明

NF023 hexasodium is a selective and competitive P2X1 receptor antagonist, with IC50 values of 0.21 μM, 28.9 μM, > 50 μM and > 100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively[1][2][3][4].

IC50 & Target

p2x1 Receptor

 

体外実験

NF023 is selective for recombinant Gi alpha-1 and recombinant Go alpha (EC50 value of approximately 300 nM)[2].
NF023 inhibits P2X1 receptors in a voltage-insensitive manner. NF023 (5 and 30 μM) causes a shift of the concentration-response curve to the right without affecting the maximal response to ATP (KB=1.190.2 μM)[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NF023 (hexasodium) 関連抗体
体内実験

NF023 (100 μmol/kg i.v.) antagonizes vasopressor responses to α,β-mATP but not to noradrenaline In pithed rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1162.88

分子式

C35H20N4Na6O21S6
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC(NC(NC2=CC(C(NC(C(C([S](=O)(O[Na])=O)=C3)=C4C=C3[S](=O)(O[Na])=O)=CC=C4[S](=O)(O[Na])=O)=O)=CC=C2)=O)=CC=C1)NC(C(C([S](=O)(O[Na])=O)=C5)=C6C=C5[S](=O)(O[Na])=O)=CC=C6[S](=O)(O[Na])=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

H2O : ≥ 116.3 mg/mL (100.01 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8599 mL 4.2997 mL 8.5993 mL
5 mM 0.1720 mL 0.8599 mL 1.7199 mL
10 mM 0.0860 mL 0.4300 mL 0.8599 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

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体積 （終了）

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.99%

COA (252 KB) HNMR (449 KB) RP-HPLC (206 KB) MS (73 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.8599 mL 4.2997 mL 8.5993 mL 21.4983 mL
5 mM 0.1720 mL 0.8599 mL 1.7199 mL 4.2997 mL
10 mM 0.0860 mL 0.4300 mL 0.8599 mL 2.1498 mL
15 mM 0.0573 mL 0.2866 mL 0.5733 mL 1.4332 mL
20 mM 0.0430 mL 0.2150 mL 0.4300 mL 1.0749 mL
25 mM 0.0344 mL 0.1720 mL 0.3440 mL 0.8599 mL
30 mM 0.0287 mL 0.1433 mL 0.2866 mL 0.7166 mL
40 mM 0.0215 mL 0.1075 mL 0.2150 mL 0.5375 mL
50 mM 0.0172 mL 0.0860 mL 0.1720 mL 0.4300 mL
60 mM 0.0143 mL 0.0717 mL 0.1433 mL 0.3583 mL
80 mM 0.0107 mL 0.0537 mL 0.1075 mL 0.2687 mL
100 mM 0.0086 mL 0.0430 mL 0.0860 mL 0.2150 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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NF023 hexasodium Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NF023 hexasodium104869-31-0P2X ReceptorP2XRsInhibitorinhibitorinhibit

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