2. JAK/STAT Signaling
  3. Pim
  4. NMS-P645

NMS-P645 is a PIM1 inhibitor. NMS-P645 exhibits anti-proliferative activity when combined with GDC-0941 (HY-50094) in TMPRSS2/ERG positive and negative PCa cells. NMS-P645 can reverse PIM1-induced pro-survival signals in prostate cells. NMS-P645 can be studied in research on prostate cancer.

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NMS-P645

NMS-P645 화학구조

CAS No. : 1482518-95-5

사이즈 재고
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100 mg   견적 받기  
250 mg   견적 받기  

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This product is a controlled substance and not for sale in your territory.

NMS-P645 Related Antibodies

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PIM1 PIM2 PIM3

  • Biological Activity

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  • References

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제품 설명

NMS-P645 is a PIM1 inhibitor. NMS-P645 exhibits anti-proliferative activity when combined with GDC-0941 (HY-50094) in TMPRSS2/ERG positive and negative PCa cells. NMS-P645 can reverse PIM1-induced pro-survival signals in prostate cells. NMS-P645 can be studied in research on prostate cancer[1].

Cellular Effect
Cell Line Type Value Description References
BaF3 IC50
0.125 3
Compound: 15a
Cytotoxicity against mouse BA/F3 cells overexpressing PIM1 after 72 hrs by CellTitre-Glo assay
Cytotoxicity against mouse BA/F3 cells overexpressing PIM1 after 72 hrs by CellTitre-Glo assay
[PMID: 24139169]
BaF3 IC50
> 10 3
Compound: 15a
Cytotoxicity against mouse BA/F3 cells after 72 hrs by CellTitre-Glo assay
Cytotoxicity against mouse BA/F3 cells after 72 hrs by CellTitre-Glo assay
[PMID: 24139169]
CAPAN-1 IC50
3.704 3
Compound: 15a
Cytotoxicity against human Capan1 cells after 72 hrs by CellTitre-Glo assay
Cytotoxicity against human Capan1 cells after 72 hrs by CellTitre-Glo assay
[PMID: 24139169]
KMS-11 IC50
7.134 3
Compound: 15a
Cytotoxicity against human KMS11 cells after 72 hrs by CellTitre-Glo assay
Cytotoxicity against human KMS11 cells after 72 hrs by CellTitre-Glo assay
[PMID: 24139169]
LNCaP IC50
3.313 3
Compound: 15a
Cytotoxicity against human LNCAP cells after 72 hrs by CellTitre-Glo assay
Cytotoxicity against human LNCAP cells after 72 hrs by CellTitre-Glo assay
[PMID: 24139169]
LP-1 IC50
1.929 3
Compound: 15a
Cytotoxicity against human LP-1 cells after 72 hrs by CellTitre-Glo assay
Cytotoxicity against human LP-1 cells after 72 hrs by CellTitre-Glo assay
[PMID: 24139169]
MV4-11 IC50
1.529 3
Compound: 15a
Cytotoxicity against human MV4-11 cells after 72 hrs by CellTitre-Glo assay
Cytotoxicity against human MV4-11 cells after 72 hrs by CellTitre-Glo assay
[PMID: 24139169]
NCI-H929 IC50
5.928 3
Compound: 15a
Cytotoxicity against human NCI-H929 cells after 72 hrs by CellTitre-Glo assay
Cytotoxicity against human NCI-H929 cells after 72 hrs by CellTitre-Glo assay
[PMID: 24139169]
RPMI-8226 IC50
6.658 3
Compound: 15a
Cytotoxicity against human RPMI8226 cells after 72 hrs by CellTitre-Glo assay
Cytotoxicity against human RPMI8226 cells after 72 hrs by CellTitre-Glo assay
[PMID: 24139169]
분자량

512.09

화학식

C28H38ClN5O2
CAS No.
SMILES

O=C(N[C@@H](C1CCCCC1)CN2CCN(C)CC2)C[C@H]3CNC(C4=CC(C5=CC=CC(Cl)=C5)=CN43)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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NMS-P645 Related Classifications

  • 몰농도 계산기

  • 농도 희석 계산기

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NMS-P6451482518-95-5PimPim kinasesInhibitorinhibitorinhibit

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상품명:
NMS-P645
Cat. No.:
HY-117744
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