2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. NOTA-AUNP-12

NOTA-AUNP-12 is a PD-L1 antagonist (IC50=2.24×10−7 M). NOTA-AUNP-12 is promising for research of cancers (e.g., lung/esophageal cancers).

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Synthèse de peptides personnalisée

NOTA-AUNP-12

NOTA-AUNP-12 Chemical Structure

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NOTA-AUNP-12 Related Antibodies

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Description

NOTA-AUNP-12 is a PD-L1 antagonist (IC50=2.24×10−7 M). NOTA-AUNP-12 is promising for research of cancers (e.g., lung/esophageal cancers)[1].

Masse moléculaire

3546.85

Formule

C154H245N43O53
Sequence

NOTA-Ser-Asn-Thr-Ser-Glu-Ser-Phe-Lys(Ser-Asn-Thr-Ser-Glu-Ser-Phe)-Phe-Arg-Val-Thr-Gln-Leu-Ala-Pro-Lys-Ala-Gln-Ile-Lys-Glu-NH2
Sequence Shortening

NOTA-SNTSESF-K(SNTSESF)-FRVTQLAPKAQIKE-NH2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvant et solubilité
In Vitro: 

H2O : ≥ 100 mg/mL (28.19 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2819 mL 1.4097 mL 2.8194 mL
5 mM 0.0564 mL 0.2819 mL 0.5639 mL
View the Complete Stock Solution Preparation Table

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureté et documentation
Références

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.2819 mL 1.4097 mL 2.8194 mL 7.0485 mL
5 mM 0.0564 mL 0.2819 mL 0.5639 mL 1.4097 mL
10 mM 0.0282 mL 0.1410 mL 0.2819 mL 0.7049 mL
15 mM 0.0188 mL 0.0940 mL 0.1880 mL 0.4699 mL
20 mM 0.0141 mL 0.0705 mL 0.1410 mL 0.3524 mL
25 mM 0.0113 mL 0.0564 mL 0.1128 mL 0.2819 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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NOTA-AUNP-12 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NOTA-AUNP-12PD-1/PD-L1PD-1/Programmed death-ligand 1PD-L1cancersInhibitorinhibitorinhibit

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