PBI-6DNJ
PBI-6DNJ is an orally active and potent multivalent glycosidase inhibitor. PBI-6DNJ exhibits good inhibition activity against α-glucosidase from mice, with a Ki of 0.14 μM. PBI-6DNJ exhibits good hypoglycemic activity. PBI-6DNJ can be used for type 2 diabetes research.
For research use only. We do not sell to patients.
- CAS No.: 2857098-72-5
- Formula: C120H146N26O36
- Molecular Weight:2528.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Ki: 0.02 ± 0.002 μM (α-glucosidase from rice), 0.08 ± 0.03 μM (α-mannosidase from jack bean), 0.14 ± 0.007 μM (α-glucosidase from mice), 18.88 ± 0.30 μM (α-glucosidase from aspergilcus niger)[1]
PBI-6DNJ (2.0 mg/kg, Orally, daily for 7 day) has good biocompatibility and no damage to mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL-6J mice (twenty-eight, 4-5 weeks old, 18-20 g)[1]
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Dosage:0.5, 1.0 and 2.0 mg/kg
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Administration:Orally, once
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Result:Reduced postprandial blood glucose (PBG) level, resulting in 24.41 ± 3.02%, 34.65 ± 9.66%, and 37.77 ± 4.35% of decreases in PBG levels at the doses of 0.5, 1.0 and 2.0 mg/kg, respectively.
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Animal Model:C57BL-6J mice (twenty-eight, 4-5 weeks old, 18-20 g)[1]
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Dosage:2.0 mg/kg
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Administration:Orally, daily for 7 day
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Result:Resulted in increase of the level of UREA (8.63 ± 0.59 mmol/L) and decrease of the level of UA level (242.06 ± 14.77 μmol/L). No obvious differences in the levels of UREA and UA were observed. Showed a slight decrease of 0.30 mmol/L in the level of LDL. The AST level of PBI-6DNJ group (269.71 ± 39.77 U/L) was higher than that of the control group (221.38 ± 23.03 U/L), and the ALT level (59.14 ± 7.13 U/L) was lower than that of the control group (70.49 ± 8.78U/L).
Chemical Information
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CAS No. 2857098-72-5
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Molecular Weight 2528.60
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Formula C120H146N26O36
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SMILES
OC[C@H]1[C@@H]([C@H]([C@@H](CN1CCCN2C=C(COC3=CC=C(C=C3)OC4=CC(C(N5CC6=CN(CCCN7[C@@H](CO)[C@@H]([C@H]([C@@H](C7)O)O)O)N=N6)=O)=C8C9=C4C%10=C%11C(C(C%12=O)=CC(OC%13=CC=C(C=C%13)OCC%14=CN(CCCN%15[C@H](CO)[C@H]([C@@H]([C@H](C%15)O)O)O)N=N%14)=C%11C9=C(C=C8C5=O)OC%16=CC=C(C=C%16)OCC%17=CN(CCCN(C[C@H]([C@@H]([C@H]%18O)O)O)[C@H]%18CO)N=N%17)=C(C=C%10OC%19=CC=C(OCC%20=CN(CCCN%21[C@H](CO)[C@H]([C@@H]([C@H](C%21)O)O)O)N=N%20)C=C%19)C(N%12CC%22=CN(CCCN%23[C@H](CO)[C@H]([C@@H]([C@H](C%23)O)O)O)N=N%22)=O)N=N2)O)O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PBI-6DNJ Related Classifications
HY-150723 Related Classifications
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