1. Metabolic Enzyme/Protease
  2. Glucosidase
  3. PBI-6DNJ

PBI-6DNJ 

Cat. No.: HY-150723
Handling Instructions

PBI-6DNJ is an orally active and potent multivalent glycosidase inhibitor. PBI-6DNJ exhibits good inhibition activity against α-glucosidase from mice, with a Ki of 0.14 μM. PBI-6DNJ exhibits good hypoglycemic activity. PBI-6DNJ can be used for type 2 diabetes research.

For research use only. We do not sell to patients.

PBI-6DNJ Chemical Structure

PBI-6DNJ Chemical Structure

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Description

PBI-6DNJ is an orally active and potent multivalent glycosidase inhibitor. PBI-6DNJ exhibits good inhibition activity against α-glucosidase from mice, with a Ki of 0.14 μM. PBI-6DNJ exhibits good hypoglycemic activity. PBI-6DNJ can be used for type 2 diabetes research[1].

IC50 & Target

Ki: 0.02 ± 0.002 μM (α-glucosidase from rice), 0.08 ± 0.03 μM (α-mannosidase from jack bean), 0.14 ± 0.007 μM (α-glucosidase from mice), 18.88 ± 0.30 μM (α-glucosidase from aspergilcus niger)[1]

In Vivo

PBI-6DNJ (0-2 mg/kg, Orally, once) reduces postprandial blood glucose (PBG) levels[1].
PBI-6DNJ (2.0 mg/kg, Orally, daily for 7 day) has good biocompatibility and no damage to mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL-6J mice (twenty-eight, 4-5 weeks old, 18-20 g)[1]
Dosage: 0.5, 1.0 and 2.0 mg/kg
Administration: Orally, once
Result: Reduced postprandial blood glucose (PBG) level, resulting in 24.41 ± 3.02%, 34.65 ± 9.66%, and 37.77 ± 4.35% of decreases in PBG levels at the doses of 0.5, 1.0 and 2.0 mg/kg, respectively.
Animal Model: C57BL-6J mice (twenty-eight, 4-5 weeks old, 18-20 g)[1]
Dosage: 2.0 mg/kg
Administration: Orally, daily for 7 day
Result: Resulted in increase of the level of UREA (8.63 ± 0.59 mmol/L) and decrease of the level of UA level (242.06 ± 14.77 μmol/L). No obvious differences in the levels of UREA and UA were observed. Showed a slight decrease of 0.30 mmol/L in the level of LDL. The AST level of PBI-6DNJ group (269.71 ± 39.77 U/L) was higher than that of the control group (221.38 ± 23.03 U/L), and the ALT level (59.14 ± 7.13 U/L) was lower than that of the control group (70.49 ± 8.78U/L).
Molecular Weight

2528.60

Formula

C120H146N26O36

SMILES

OC[[email protected]]1[[email protected]@H]([[email protected]]([[email protected]@H](CN1CCCN2C=C(COC3=CC=C(C=C3)OC4=CC(C(N5CC6=CN(CCCN7[[email protected]@H](CO)[[email protected]@H]([[email protected]]([[email protected]@H](C7)O)O)O)N=N6)=O)=C8C9=C4C%10=C%11C(C(C%12=O)=CC(OC%13=CC=C(C=C%13)OCC%14=CN(CCCN%15[[email protected]](CO)[[email protected]]([[email protected]@H]([[email protected]](C%15)O)O)O)N=N%14)=C%11C9=C(C=C8C5=O)OC%16=CC=C(C=C%16)OCC%17=CN(CCCN(C[[email protected]]([[email protected]@H]([[email protected]]%18O)O)O)[[email protected]]%18CO)N=N%17)=C(C=C%10OC%19=CC=C(OCC%20=CN(CCCN%21[[email protected]](CO)[[email protected]]([[email protected]@H]([[email protected]](C%21)O)O)O)N=N%20)C=C%19)C(N%12CC%22=CN(CCCN%23[[email protected]](CO)[[email protected]]([[email protected]@H]([[email protected]](C%23)O)O)O)N=N%22)=O)N=N2)O)O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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PBI-6DNJ
Cat. No.:
HY-150723
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