2. GPCR/G Protein
  3. Angiotensin Receptor
  4. PD 123319

PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.

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No. CAS : 130663-39-7

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PD 123319 Related Antibodies

Top Publications Citing Use of Products

    PD 123319 purchased from MedChemExpress. Usage Cited in: FASEB J. 2018 Sep;32(9):5051-5062.  [Abstract]

    HUVECs are starved for 12 h, treated with 10 mg/mL (9.56 μM) of AngII with or without Losartan or PD123319 for 12 h, and are subsequently used for Western blot analysis.

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    AT1 Receptor AT2 Receptor

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    Descripciòn

    PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.

    IC50 & Target

    AT2 Receptor

     

    In Vitro

    PD 123319 is shown to discriminate between two subclasses of AII receptors in many different tissues. 125I-AII specifically label two classes of binding sites for AII in a membrane preparation of bovine adrenal glomerulosa cells. The first class (DuP-753 sensitive) represents approximately 85% of the total binding sites for AII and possesses a high affinity (IC50 of 92.9 nM) for DuP-753. PD-123319 does not have any effect on 125I-AII binding to this site. The second class of binding sites is more sensitive to PD-123319, with an IC50 of 6.9 nM, and has a much lower affinity for DuP-753 (IC50 around 10 microM)[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    PD 123319 Related Antibodies
    Peso molecular

    508.61

    Fòrmula

    C31H32N4O3
    No. CAS
    SMILES

    O=C([C@@H]1CC2=C(N=CN2CC3=CC=C(N(C)C)C(C)=C3)CN1C(C(C4=CC=CC=C4)C5=CC=CC=C5)=O)O
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    Administraciòn de animales
    [3]

    The lower limit of CBF autoregulation is studied in 16 SHR. Eight animals receive PD 123319, while eight serve as controls. PD 123319 or saline is administered intravenously, and the BP is allowed to stabilise for 10 minutes after the injection and prior to the commencement of the autoregulation study. Haemorrhagic hypotension is subsequently induced by withdrawing blood into a syringe. By this means, BP is reduced stepwise to the lowest obtainable level. Throughout the study, CBF is measured at 10 to 15 mmHg BP intervals.

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    PD 123319 Related Classifications

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    Keywords:

    PD 123319130663-39-7(S)-(+)-PD 123319PD123319PD-123319Angiotensin ReceptorInhibitorinhibitorinhibit

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    Nombre del producto:
    PD 123319
    Cat. No.:
    HY-10259
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