PD-L1-IN-9
PD-L1-IN-9 is a PD-L1 inhibitor with an IC50 of 110.85 nM. PD-L1-IN-9 has a Kd of 319 nM for human PD-L1 and a Kd of 450 nM for murine PD-L1. PD-L1-IN-9 blocks the PD-1/PD-L1 interaction, restores T cell-mediated anti-tumor immunity, and induces PD-L1 degradation in tumor tissues. PD-L1-IN-9 exhibits anti-tumor activity and can be used in the research of tumors such as melanoma.
For research use only. We do not sell to patients.
- Formula: C29H29N3O4
- Molecular Weight:483.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
PD-L1-IN-9 (Compound Z38) (48 h) shows low cytotoxicity against B16-F10, Jurkat, HepG2, HCT116 and HeLa cell lines, with IC50 values ranging from 28.18 μM to > 40 μM[1].
PD-L1-IN-9 (1.5625-25 μM; 48 h) induces HepG2 cell death in a dose-dependent manner by reactivating T cells in the HepG2/Jurkat co-culture system[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2/Jurkat T cell coculture system
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Concentration:1.5625, 3.125, 6.25, 12.5 and 25 μM
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Incubation Time:48 h
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Result:Promoted dose-dependent death of HepG2 cells, reducing HepG2 cell viability to 75.26% at 25 μM by reactivating Jurkat T cells to mediate killing.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (male, 6 weeks old, melanoma model via subcutaneous injection of B16-F10 cells)[1]
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Dosage:15, 30 mg/kg
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Administration:i.p.; daily; 7 consecutive days
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Result:Achieved 34% tumor growth inhibition rate (TGI), increased tumor-infiltrating CD4⁺ T cells to 14.9% and CD8⁺ T cells to 22.4%, and induced ~49% PD-L1 degradation in tumor tissues at 15 mg/kg.
Achieved 60% TGI, increased tumor-infiltrating CD4⁺ T cells to 19.3% and CD8⁺ T cells to 26.6%, and induced ~51% PD-L1 degradation in tumor tissues at 30 mg/kg.
Chemical Information
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Molecular Weight 483.56
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Formula C29H29N3O4
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SMILES
CC1=C(C2=NC(N(C)C=C3CN4CC[C@@H](C(O)=O)C4)=C3C=C2)C=CC=C1C5=CC6=C(OCCO6)C=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PD-L1-IN-9 Related Classifications
HY-181096 Related Classifications
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