1. PI3K/Akt/mTOR
  2. PDK-1
  3. MP7

MP7 (Synonyms: PDK1 inhibitor)

Cat. No.: HY-14440 Purity: 99.83%
Handling Instructions

MP7 (PDK1 inhibitor) is a phosphoinositide-dependent kinase-1 (PDK1) inhibitor.

For research use only. We do not sell to patients.

MP7 Chemical Structure

MP7 Chemical Structure

CAS No. : 1001409-50-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 182 In-stock
Estimated Time of Arrival: December 31
5 mg USD 160 In-stock
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10 mg USD 295 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1110 In-stock
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100 mg USD 1680 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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MP7 (PDK1 inhibitor) is a phosphoinositide-dependent kinase-1 (PDK1) inhibitor.

IC50 & Target


In Vitro

Cell counting of U87MG-derived glioma stem cells (GSCs) confirms that Alisertib and, to a minor extent, MP7 (PDK1 inhibitor) are able to decrease the number of viable cells. When combined together, GSC viability is further reduced with respect to single-treated cells. As observed in U87MG cells, when used at the highest concentrations (i.e., 1.5 μM Alisertib and 2.5 μM MP7), a significant enhancement in the number of dead cells is evidenced. Following 72 h treatment, MP7 alone does not show a significant inhibition of glioblastoma multiforme (GBM) proliferation. MP7 has been shown to have only minimal effects on monolayer cell growth in several cancer cell lines, with IC50 values in the micromolar range[1].

Molecular Weight







O=C(C1=CC=CN(CC2=CC=C(F)C(F)=C2)C1=O)N[[email protected]](C3=CC=CC=C3)COC4=CC=C(N5)C(NC5=O)=C4


Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (193.61 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9361 mL 9.6805 mL 19.3611 mL
5 mM 0.3872 mL 1.9361 mL 3.8722 mL
10 mM 0.1936 mL 0.9681 mL 1.9361 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.75 mg/mL (5.32 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.75 mg/mL (5.32 mM); Clear solution

*All of the co-solvents are provided by MCE.
Cell Assay

The human GBM cells (i.e., U87MG, U343MG, or ANGM-CSS) or the respective GSCs are seeded and incubated for the indicated times with the indicated concentrations of SA16 (1 nM to 100 μM), MP7 (2.5 nM, 25 nM, 250 nM and 2.5 μM), or Alisertib. When indicated, cells are treated with MP7 and Alisertib in combination. To verify GSC chemoresistance, U87MG or GSCs are incubated with 50 μM TMZ for 72 h. For the long-term treatment of cells, NSC or complete medium containing drugs is replaced every 3 days. Cell proliferation is determined using the MTS assay: the dehydrogenase activity in active mitochondria reduces MTS to the soluble formazan product, whose absorbance at 490 nm is measured with an automated plate reader. The mean background from each test condition is subtracted, and the data are expressed as the percentage of untreated cells (control). IC50 values are derived from the sigmoid dose-response curve. The percentage of inhibition is calculated as 100% minus the percentage of cell proliferation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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MP7PDK1 inhibitorMP 7MP-7PDK-1Phosphoinositide dependent protein kinase-1phosphoinositide-dependentkinase-1PDK1Inhibitorinhibitorinhibit

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