2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Phenibut hydrochloride

Phenibut hydrochloride  (Synonyms: β-Phenyl-GABA hydrochloride; 4-Amino-3-phenylbutanoic acid hydrochloride; 4-Amino-3-phenylbutyric acid hydrochloride)

製品番号: HY-W041333 純度: 98.0%
COA 取扱説明書 Technical Support

Phenibut (β-Phenyl-GABA) hydrochloride is an orally active GABA-B agonist. Phenibut hydrochloride acts as a GABA-mimetic, primarily at GABAB?receptors. Phenibut hydrochloride has anxiolytic and nootropic (cognition enhancing) effects.

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Phenibut hydrochloride

Phenibut hydrochloride 構造式

CAS 番号 : 3060-41-1

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 在庫あり
Solution
10 mM * 1 mL in DMSO USD 55 在庫あり
Solid
5 g $50 在庫あり
10 g $80 在庫あり
25 g $165 在庫あり
50 g $295 在庫あり
100 g $530 在庫あり
> 100 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Other Forms of Phenibut hydrochloride:

Phenibut hydrochloride 関連抗体

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製品説明

Phenibut (β-Phenyl-GABA) hydrochloride is an orally active GABA-B agonist[1]. Phenibut hydrochloride acts as a GABA-mimetic, primarily at GABAB?receptors. Phenibut hydrochloride has anxiolytic and nootropic (cognition enhancing) effects[2].

IC50 & Target

GABA-B[1][2]
体外実験

Phenibut hydrochloride is a neuropsychotropic agent. Phenibut hydrochloride also stimulates dopamine receptors and antagonizes β-phenethylamine (PEA), a putative endogenous anxiogenic[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Phenibut hydrochloride 関連抗体
分子量

215.68

分子式

C10H14ClNO2
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CC(C1=CC=CC=C1)CN.[H]Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

H2O : 100 mg/mL (463.65 mM; Need ultrasonic)

DMSO : 100 mg/mL (463.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6365 mL 23.1825 mL 46.3650 mL
5 mM 0.9273 mL 4.6365 mL 9.2730 mL
10 mM 0.4636 mL 2.3182 mL 4.6365 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 5 mg/mL (23.18 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 5 mg/mL (23.18 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: ≥98.0%

COA (245 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 4.6365 mL 23.1825 mL 46.3650 mL 115.9125 mL
5 mM 0.9273 mL 4.6365 mL 9.2730 mL 23.1825 mL
10 mM 0.4636 mL 2.3182 mL 4.6365 mL 11.5912 mL
15 mM 0.3091 mL 1.5455 mL 3.0910 mL 7.7275 mL
20 mM 0.2318 mL 1.1591 mL 2.3182 mL 5.7956 mL
25 mM 0.1855 mL 0.9273 mL 1.8546 mL 4.6365 mL
30 mM 0.1545 mL 0.7727 mL 1.5455 mL 3.8637 mL
40 mM 0.1159 mL 0.5796 mL 1.1591 mL 2.8978 mL
50 mM 0.0927 mL 0.4636 mL 0.9273 mL 2.3182 mL
60 mM 0.0773 mL 0.3864 mL 0.7727 mL 1.9319 mL
80 mM 0.0580 mL 0.2898 mL 0.5796 mL 1.4489 mL
100 mM 0.0464 mL 0.2318 mL 0.4636 mL 1.1591 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Phenibut hydrochloride Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phenibut3060-41-1β-Phenyl-GABA4-Amino-3-phenylbutanoic acid4-Amino-3-phenylbutyric acidGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptorneuropsychotropicβ-phenethylaminePEAendogenousanxiogenicInhibitorinhibitorinhibit

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Phenibut hydrochloride
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