2. Immunology/Inflammation
  3. PSMA
  4. Piflufolastat

Piflufolastat  (Synonyms: DCFPYL)

製品番号: HY-117756 純度: 99.49%
COA 取扱説明書 Technical Support

Piflufolastat (DCFPYL) can be used for the preparation of piflufolastat F 18 (DCFPyL F-18). Piflufolastat F-18 (DCFPyL F-18) is an 18F-labeled imaging agent. Piflufolastat F-18 can be used for positron emission tomography (PET) targeting prostate-specific membrane antigen (PSMA). Piflufolastat can be used for imaging of prostate cancer.

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Piflufolastat

Piflufolastat 構造式

CAS 番号 : 1423758-00-2

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 165 在庫あり
Solution
10 mM * 1 mL in DMSO USD 165 在庫あり
Solid
5 mg $150 在庫あり
10 mg $250 在庫あり
25 mg $550 在庫あり
50 mg $950 在庫あり
100 mg $1650 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Piflufolastat 関連抗体

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製品説明

Piflufolastat (DCFPYL) can be used for the preparation of piflufolastat F 18 (DCFPyL F-18). Piflufolastat F-18 (DCFPyL F-18) is an 18F-labeled imaging agent. Piflufolastat F-18 can be used for positron emission tomography (PET) targeting prostate-specific membrane antigen (PSMA). Piflufolastat can be used for imaging of prostate cancer[1][2].

Cellular Effect
Cell Line Type Value Description References
LNCaP IC50
1.56 nM
Compound: 1; DCFPyL
Inhibition of PSMA in human LNCaP cell extracts in presence of N-acetylaspartylglutamate by Amplex red glutamic acid dependent fluorescence-based NAALADase assay
Inhibition of PSMA in human LNCaP cell extracts in presence of N-acetylaspartylglutamate by Amplex red glutamic acid dependent fluorescence-based NAALADase assay
[PMID: 32097010]
体外実験

Piflufolastat (DCFPYL) can be used for the preparation of piflufolastat F 18 (DCFPyL F-18)[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Piflufolastat 関連抗体
分子量

442.40

分子式

C18H23FN4O8
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(CC[C@H](NC(N[C@@H](CCCCNC(C1=CC=C(N=C1)F)=O)C(O)=O)=O)C(O)=O)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Sealed storage, away from moisture
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 175 mg/mL (395.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2604 mL 11.3020 mL 22.6040 mL
5 mM 0.4521 mL 2.2604 mL 4.5208 mL
10 mM 0.2260 mL 1.1302 mL 2.2604 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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(per animal)

g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2604 mL 11.3020 mL 22.6040 mL 56.5099 mL
5 mM 0.4521 mL 2.2604 mL 4.5208 mL 11.3020 mL
10 mM 0.2260 mL 1.1302 mL 2.2604 mL 5.6510 mL
15 mM 0.1507 mL 0.7535 mL 1.5069 mL 3.7673 mL
20 mM 0.1130 mL 0.5651 mL 1.1302 mL 2.8255 mL
25 mM 0.0904 mL 0.4521 mL 0.9042 mL 2.2604 mL
30 mM 0.0753 mL 0.3767 mL 0.7535 mL 1.8837 mL
40 mM 0.0565 mL 0.2825 mL 0.5651 mL 1.4127 mL
50 mM 0.0452 mL 0.2260 mL 0.4521 mL 1.1302 mL
60 mM 0.0377 mL 0.1884 mL 0.3767 mL 0.9418 mL
80 mM 0.0283 mL 0.1413 mL 0.2825 mL 0.7064 mL
100 mM 0.0226 mL 0.1130 mL 0.2260 mL 0.5651 mL
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Piflufolastat Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Piflufolastat1423758-00-2DCFPYLPSMAProstate-specific membrane antigenandrogen receptor-positive metastatic breast cancermalignant prostate cancer cellsHER2-negativeprostate cancerPET imagingPSMA-positive lesionsclear cell renal cell carcinomaPSMA-expressing cellsInhibitorinhibitorinhibit

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製品名:
Piflufolastat
製品番号:
HY-117756
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