2. JAK/STAT Signaling
  3. Pim
  4. PIM3-IN-1 hydrochloride

PIM3-IN-1 hydrochloride (Compound 19a) is an inhibitor of (PIM2/3), with the highest inhibition level being against PIM3, having an IC50 value in the nanomolar range. PIM3-IN-1 hydrochloride can be used in cancer research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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PIM3-IN-1 hydrochloride

PIM3-IN-1 hydrochloride 構造式

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PIM3-IN-1 hydrochloride 関連抗体

Top Publications Citing Use of Products

Pim アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
PIM1 PIM2 PIM3

  • 生物活性

  • 純度とドキュメンテーション

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製品説明

PIM3-IN-1 hydrochloride (Compound 19a) is an inhibitor of (PIM2/3), with the highest inhibition level being against PIM3, having an IC50 value in the nanomolar range. PIM3-IN-1 hydrochloride can be used in cancer research[1].

IC50 & Target

PIM2

 

PIM3

 

Cellular Effect
Cell Line Type Value Description References
H9c2 EC50
5.3 μM
Compound: 19a
Cytotoxicity against rat H9c2 cells assessed as reduction in cell viability incubated for 24 hrs by WST-1 assay
Cytotoxicity against rat H9c2 cells assessed as reduction in cell viability incubated for 24 hrs by WST-1 assay
[PMID: 38537512]
MOLM-13 EC50
0.21 μM
Compound: 19a
Cytotoxicity against human MOLM-13 cells assessed as induction of cell death incubated for 24 hrs by WST-1 assay
Cytotoxicity against human MOLM-13 cells assessed as induction of cell death incubated for 24 hrs by WST-1 assay
[PMID: 38537512]
MV4-11 EC50
0.45 μM
Compound: 19a
Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability incubated for 24 hrs by WST-1 assay
Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability incubated for 24 hrs by WST-1 assay
[PMID: 38537512]
NRK EC50
4 μM
Compound: 19a
Cytotoxicity against rat NRK cells assessed as reduction in cell viability incubated for 24 hrs by WST-1 assay
Cytotoxicity against rat NRK cells assessed as reduction in cell viability incubated for 24 hrs by WST-1 assay
[PMID: 38537512]
OCI-AML-3 EC50
0.64 μM
Compound: 19a
Cytotoxicity against human OCI-AML-3 cells assessed as reduction in cell viability incubated for 24 hrs by WST-1 assay
Cytotoxicity against human OCI-AML-3 cells assessed as reduction in cell viability incubated for 24 hrs by WST-1 assay
[PMID: 38537512]
分子量

440.37

分子式

C23H23Cl2N5
SMILES

CNCCCN1C2=CC=CC=C2C3=C1C4=C(C5=C3C=NN5)C6=C(N4)C=CC=C6.Cl.Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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PIM3-IN-1 hydrochloride Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PIM3-IN-1PimPim kinasesMOLM-13OCI-AML3MV4-11acute myeloid leukemia (AML)Inhibitorinhibitorinhibit

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製品名:
PIM3-IN-1 hydrochloride
製品番号:
HY-163442A
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