2. JAK/STAT Signaling
  3. Pim
  4. PIM3-IN-1 hydrochloride

PIM3-IN-1 hydrochloride (Compound 19a) is an inhibitor of (PIM2/3), with the highest inhibition level being against PIM3, having an IC50 value in the nanomolar range. PIM3-IN-1 hydrochloride can be used in cancer research.

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PIM3-IN-1 hydrochloride

PIM3-IN-1 hydrochloride 화학구조

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PIM3-IN-1 hydrochloride Related Antibodies

Top Publications Citing Use of Products

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View All Isoforms
PIM1 PIM2 PIM3

  • Biological Activity

  • 순도&문서

  • References

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제품 설명

PIM3-IN-1 hydrochloride (Compound 19a) is an inhibitor of (PIM2/3), with the highest inhibition level being against PIM3, having an IC50 value in the nanomolar range. PIM3-IN-1 hydrochloride can be used in cancer research[1].

IC50 & Target

PIM2

 

PIM3

 

Cellular Effect
Cell Line Type Value Description References
H9c2 EC50
5.3 μM
Compound: 19a
Cytotoxicity against rat H9c2 cells assessed as reduction in cell viability incubated for 24 hrs by WST-1 assay
Cytotoxicity against rat H9c2 cells assessed as reduction in cell viability incubated for 24 hrs by WST-1 assay
[PMID: 38537512]
MOLM-13 EC50
0.21 μM
Compound: 19a
Cytotoxicity against human MOLM-13 cells assessed as induction of cell death incubated for 24 hrs by WST-1 assay
Cytotoxicity against human MOLM-13 cells assessed as induction of cell death incubated for 24 hrs by WST-1 assay
[PMID: 38537512]
MV4-11 EC50
0.45 μM
Compound: 19a
Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability incubated for 24 hrs by WST-1 assay
Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability incubated for 24 hrs by WST-1 assay
[PMID: 38537512]
NRK EC50
4 μM
Compound: 19a
Cytotoxicity against rat NRK cells assessed as reduction in cell viability incubated for 24 hrs by WST-1 assay
Cytotoxicity against rat NRK cells assessed as reduction in cell viability incubated for 24 hrs by WST-1 assay
[PMID: 38537512]
OCI-AML-3 EC50
0.64 μM
Compound: 19a
Cytotoxicity against human OCI-AML-3 cells assessed as reduction in cell viability incubated for 24 hrs by WST-1 assay
Cytotoxicity against human OCI-AML-3 cells assessed as reduction in cell viability incubated for 24 hrs by WST-1 assay
[PMID: 38537512]
분자량

440.37

화학식

C23H23Cl2N5
SMILES

CNCCCN1C2=CC=CC=C2C3=C1C4=C(C5=C3C=NN5)C6=C(N4)C=CC=C6.Cl.Cl
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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PIM3-IN-1 hydrochloride Related Classifications

  • 몰농도 계산기

  • 농도 희석 계산기

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PIM3-IN-1PimPim kinasesMOLM-13OCI-AML3MV4-11acute myeloid leukemia (AML)Inhibitorinhibitorinhibit

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상품명:
PIM3-IN-1 hydrochloride
Cat. No.:
HY-163442A
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