2. Metabolic Enzyme/Protease
  3. Pyruvate Kinase
  4. PKL-IN-1

PKL-IN-1 is a potent inhibitor of pyruvate kinase (PKL) with an IC50 of 0.07 μM. PKL-IN-1 can be used in the study of non-alcoholic fatty liver disease.

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PKL-IN-1

PKL-IN-1 構造式

CAS 番号 : 3078059-66-9

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 561 在庫あり
Solution
10 mM * 1 mL in DMSO USD 561 在庫あり
Solid
1 mg $204 在庫あり
5 mg $510 在庫あり
10 mg $820 在庫あり
25 mg $1600 在庫あり
50 mg $2600 在庫あり
100 mg   お問い合わせ  
200 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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PKL-IN-1 関連抗体

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製品説明

PKL-IN-1 is a potent inhibitor of pyruvate kinase (PKL) with an IC50 of 0.07 μM. PKL-IN-1 can be used in the study of non-alcoholic fatty liver disease[1].

IC50 & Target

IC50: 0.07 μM (PKL)[1]
体外実験

PKL-IN-1 (Compound 12a) (10 μM; 5 min) inhibits PKL activity by 96.6%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PKL-IN-1 関連抗体
分子量

312.25

分子式

C12H8O8S
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

OC1=C(O)C=C(C(C(O)=C(O)C(O)=C2)=C2OS3(=O)=O)C3=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 125 mg/mL (400.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2026 mL 16.0128 mL 32.0256 mL
5 mM 0.6405 mL 3.2026 mL 6.4051 mL
10 mM 0.3203 mL 1.6013 mL 3.2026 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2026 mL 16.0128 mL 32.0256 mL 80.0641 mL
5 mM 0.6405 mL 3.2026 mL 6.4051 mL 16.0128 mL
10 mM 0.3203 mL 1.6013 mL 3.2026 mL 8.0064 mL
15 mM 0.2135 mL 1.0675 mL 2.1350 mL 5.3376 mL
20 mM 0.1601 mL 0.8006 mL 1.6013 mL 4.0032 mL
25 mM 0.1281 mL 0.6405 mL 1.2810 mL 3.2026 mL
30 mM 0.1068 mL 0.5338 mL 1.0675 mL 2.6688 mL
40 mM 0.0801 mL 0.4003 mL 0.8006 mL 2.0016 mL
50 mM 0.0641 mL 0.3203 mL 0.6405 mL 1.6013 mL
60 mM 0.0534 mL 0.2669 mL 0.5338 mL 1.3344 mL
80 mM 0.0400 mL 0.2002 mL 0.4003 mL 1.0008 mL
100 mM 0.0320 mL 0.1601 mL 0.3203 mL 0.8006 mL
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PKL-IN-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PKL-IN-13078059-66-9Pyruvate KinaseSulfaketoneNAFLDPyruvate kinase liverSulfone heterocyclesInhibitorinhibitorinhibit

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製品名:
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製品番号:
HY-161337
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