2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. PNMT-IN-1

PNMT-IN-1 (inhibtor 4) is a specific inhibitor of phenylethanolamine N-methyltransferas (PNMT) with a Ki value of 1.2 nM and a IC50 value of 81 nM. PNMT-IN-1 also inhibits the vitality of DNMT1 and DNMT3b, with the IC50 value of 61 μM and 17 μM, respectively, and has an antagonistic effect on epinephrine.PNMT-IN-1 (inhibtor 4 ) is a second generation inhibitor.

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PNMT-IN-1

PNMT-IN-1 構造式

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PNMT-IN-1 関連抗体

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製品説明

PNMT-IN-1 (inhibtor 4) is a specific inhibitor of phenylethanolamine N-methyltransferas (PNMT) with a Ki value of 1.2 nM and a IC50 value of 81 nM. PNMT-IN-1 also inhibits the vitality of DNMT1 and DNMT3b, with the IC50 value of 61 μM and 17 μM, respectively, and has an antagonistic effect on epinephrine.PNMT-IN-1 (inhibtor 4 ) is a second generation inhibitor[1].

IC50 & Target

IC50:81 nM (Phenylethanolamine N-methyltransferase, PNMT )[1] IC50:61 nM (DNMT1)[1] IC50:17 nM (DNMT3b)[1]
体外実験

PNMT-IN-1(inhibtor 4)(0.01 μM, 4h) inhibts the activity of hPNMT (IC50= 81 nM) but don’t affect protein methylation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PNMT-IN-1 関連抗体

Cell Viability Assay

Cell Line: Overexpressed hPNMT in HEK293T cells using a lentiviral vector[1]
Concentration: 0-10 μM
Incubation Time: 24 h
Result: Inhibted the activity of hPNMT (IC50=81nM)

Western Blot Analysis

Cell Line: HT-29 cell[1]
Concentration: 10 μg
Incubation Time: 6 days
Result: Changed total SDMA, ADMA, and Me3-lysine not significant.
分子量

623.53

分子式

C27H36Cl2N8O5
SMILES

ClC1=C(Cl)C=CC2=C1CNCC2CCCCN(C[C@@H]3[C@@H](O)[C@@H](O)[C@H](N4C=NC5=C4N=CN=C5N)O3)CC[C@H](N)C(O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
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参考文献
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PNMT-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PNMT-IN-1Adrenergic ReceptorBeta ReceptorOverexpressedlentiviral vectorInhibitorinhibitorinhibit

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製品名:
PNMT-IN-1
製品番号:
HY-149389
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