Poly(D,L-lactide-co-glycolide) 

Poly(D,L-lactide-co-glycolide) is a biodegradable polymer copolymer. Poly(D,L-lactide-co-glycolide) undergoes degradation through ester bond hydrolysis into lactic acid and glycolic acid. These two products can be naturally eliminated through metabolism in the body (such as the tricarboxylic acid cycle), without the risk of long-term accumulation. Poly(D,L-lactide-co-glycolide) can be used in medical sutures, implants, and drug delivery systems^[1][2][3].

Poly(D,L-lactide-co-glycolide) forms PLGA-PEO nanoparticles, which do not exhibit significant oxidative stress induction activity and cytotoxicity towards primary rat liver cells^[1].
Poly(D,L-lactide-co-glycolide) can be used to construct drug delivery systems, which can specifically deliver drugs to tumor sites through passive targeting. By surface modification (such as PEGylation) and connection with targeting ligands (such as folic acid, transferrin, RGD peptide, antibodies, etc.), its targeting ability and therapeutic effect on other types of tumors can be significantly improved^[2].
Poly(D,L-lactide-co-glycolide) can be used to construct nanoparticles loaded with PLP (139-151) (HY-P0129) peptide, and integrate them into soluble polymer microneedle patches, thereby studying antigen-specific immunity in multiple sclerosis^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

26780-50-7

Solid

Off-white to light brown

CC(C(OCC(OC)=O)=O)C.[m].[n]

Room temperature in continental US; may vary elsewhere.

• [1]. Aranda A, et al. Dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay: a quantitative method for oxidative stress assessment of nanoparticle-treated cells. Toxicol In Vitro. 2013 Mar;27(2):954-63.  [Content Brief]

  [2]. Holgado MA, et al. Possibilities of poly(D,L-lactide-co-glycolide) in the formulation of nanomedicines against cancer. Curr Drug Targets. 2011 Jul 1;12(8):1096-111.  [Content Brief]

  [3]. Lima AF, et al. Poly(d,l-lactide-co-glycolide) (PLGA) Nanoparticles Loaded with Proteolipid Protein (PLP)-Exploring a New Administration Route. Polymers (Basel). 2020 Dec 21;12(12):3063.  [Content Brief]