26780-50-7
26780-50-7
Chemical Structure
Poly(D,L-lactide-co-glycolide)
- CAS No.: 26780-50-7
- Molecular Weight:N/A
SMILES: CC(C(OCC(OC)=O)=O)C.[m].[n]
Biological Activity: Poly(D,L-lactide-co-glycolide) is a biodegradable polymer copolymer. Poly(D,L-lactide-co-glycolide) undergoes degradation through ester bond hydrolysis into lactic acid and glycolic acid. These two products can be naturally eliminated through metabolism in the body (such as the tricarboxylic acid cycle), without the risk of long-term accumulation. Poly(D,L-lactide-co-glycolide) can be used in medical sutures, implants, and drug delivery systems[1][2][3].
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Poly(D,L-lactide-co-glycolide) | Poly(D,L-lactide-co-glycolide) is a biodegradable polymer copolymer. Poly(D,L-lactide-co-glycolide) undergoes degradation through ester bond hydrolysis into lactic acid and glycolic acid. These two products can be naturally eliminated through metabolism in the body (such as the tricarboxylic acid cycle), without the risk of long-term accumulation. Poly(D,L-lactide-co-glycolide) can be used in medical sutures, implants, and drug delivery systems. | |||||||||||||||||||||
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Poly(D,L-lactide-co-glycolide), 65:35 | Poly(D,L-lactide-co-glycolide), 65:35 (PGCL, 65:35) is a copolymer formed by the ring-opening polymerization of lactide and glycolide, which can be used for drug delivery. | |||||||||||||||||||||
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Poly(D,L-lactide-co-glycolide), 75:25 | Poly(D,L-lactide-co-glycolide), 75:25 (PGCL, 75:25) is a copolymer formed by the ring-opening polymerization of lactide and glycolide, which can be used for drug delivery. | |||||||||||||||||||||
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Poly(D,L-lactide-co-glycolide), 50:50 | Poly (D,L-lactide-co-glycolide), 50:50 (PGCL, 50:50) is a biodegradable copolymer synthesized by ring-opening polymerization of lactide and glycolide, used for controlled drug release. Poly (D,L-lactide-co-glycolide), 50:50 degrades through hydrolytic cleavage of ester bonds, and carboxylic acid groups can accelerate autocatalytic hydrolysis. Poly (D,L-lactide-co-glycolide), 50:50 can be used for research on bone defects. | |||||||||||||||||||||
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References
- [1]. Aranda A, et al. Dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay: a quantitative method for oxidative stress assessment of nanoparticle-treated cells. Toxicol In Vitro. 2013 Mar;27(2):954-63. [Content Brief]
- [2]. Holgado MA, et al. Possibilities of poly(D,L-lactide-co-glycolide) in the formulation of nanomedicines against cancer. Curr Drug Targets. 2011 Jul 1;12(8):1096-111. [Content Brief]
- [3]. Lima AF, et al. Poly(d,l-lactide-co-glycolide) (PLGA) Nanoparticles Loaded with Proteolipid Protein (PLP)-Exploring a New Administration Route. Polymers (Basel). 2020 Dec 21;12(12):3063. [Content Brief]
